Rethinking treatment for non-metastatic deficient mismatch repair colorectal and small bowel cancers

Table 1 Baseline demographic and clinical characteristics of the included patients

Patient	Tumor location	Age (years)	Sex	Medical history	Known lynch	Symptoms
P1	Small bowel	85	Male	Colon cancer (surgery 1990/2015), prostate cancer (2015)	Yex (MSH2)	Asymptomatic
P2	Colon	78	Male	COPD, OSA, moderate pulmonary hypertension, atrial fibrillation, IC-FEr (FE 35%), Moderate exertional dyspnea	No	Asymptomatic
P3	Colon	71	Female	No	No	Constitutional symptoms, malnutrition, and abdominal mass
P4	Colon	77	Female	No	No	Constitutional symptoms, anemia, malnutrition, and abdominal mass
P5	Colon	33	Male	No	No	Anemia
P6	Rectum	36	Female	First-degree lynch syndrome (MSH6)	Yes (MSH6)	Progressive weight loss and a change in bowel habits
P7	Rectum	37	Male	Grade III astrocytoma (surgery 2008/2010)	No	Rectal bleeding and a change in bowel habits
P8	Rectum	48	Female	No	No	Rectal bleeding and a change in bowel habits

COPD: Chronic obstructive pulmonary disease; OSA: Severe obstructive sleep apnea; IC-FEr (FE 35%): Heart failure with reduced ejection fraction (left ventricular ejection fraction 35%).