Tubulocystic renal cell carcinoma with aggressive behavior-insights from molecular profiling and single-cell analysis: A case report

Figure 2 Single-cell analysis reveals the characteristics of tubulocystic renal cell carcinoma. A: UMAP plots showing 23903 cells grouped into 8 groups; B: Heatmap illustrating signature genes across distinct subpopulations; C: The bar chart comparing cell type proportions across various subtypes of renal cell carcinoma and normal renal tissue; D: Copy number variation analysis distinguishing normal cells from tumor cells within epithelial populations; E: Gene set variation analysis enrichment analysis of tumor cells showing highly elevated angiogenesis scores in tubulocystic renal cell carcinoma compared to other renal cell carcinoma subtypes. CRCC: Chromophobe renal cell carcinoma; TRCC: Tubulocystic renal cell carcinoma; CCRCC: Clear cell renal cell carcinoma; UMAP: Uniform manifold approximation and projection.