Timing matters: Early vs late recurrence in nasopharyngeal carcinoma and its impact on survival

doi:10.5306/wjco.124227

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World Journal of Clinical Oncology

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2218-4333

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Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Aug 24, 2026; 17(8): 124227
Published online Aug 24, 2026. doi: 10.5306/wjco.124227

Table 3 Multivariable analysis of early vs late recurrence as a post-recurrence prognostic factor in the entire, local, regional and locoregional recurrence group

Variables	Total (n = 330)		Local (n = 167)		Regional (n = 86)		Locoregional (n = 77)
Variables	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)
Gender
Male		1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
Female	0.135	0.76 (0.53-1.09)	0.358	0.79 (0.47-1.31)	0.012	0.29 (0.11-0.76)	0.394	1.35 (0.68-2.66)
Age
< 60		1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
≥ 60	0.003	1.73 (1.21-2.48)	0.056	1.61 (0.99-2.61)	0.014	2.53 (1.20-5.31)	0.385	1.50 (0.60-3.78)
TNM
I-II		1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
III-IV	0.269	1.26 (0.84-1.88)	0.053	1.77 (0.99-3.17)	0.553	0.79 (0.36-1.74)	0.422	0.65 (0.23-1.85)
Early or late recurrence
Early		1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
Late	0.461	0.89 (0.66-1.21)	0.872	1.04 (0.67-1.59)	0.561	1.21 (0.64-2.28)	0.006	0.37 (0.19-0.76)
rTNM
I-II		1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
III-IV	< 0.001	1.88 (1.38-2.56)	0.132	1.39 (0.91-2.13)	< 0.001	3.26 (1.68-6.34)	0.451	1.32 (0.64-2.74)

rTNM: Recurrent TNM stage; HR: Hazard ratio; CI: Confidence interval.

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Citation: Wang JB, Meng Y, He ML, Zhang SJ, Huang XD, Zhang Y, Wu RY, Wang K, Chen XS, Qu Y, Zhang JH, Liu QF, Luo JW, Gao L, Xiao JP, Li YX, Luo LH, Yi JL. Timing matters: Early vs late recurrence in nasopharyngeal carcinoma and its impact on survival. World J Clin Oncol 2026; 17(8): 124227
URL: https://www.wjgnet.com/2218-4333/full/v17/i8/124227.htm
DOI: https://dx.doi.org/10.5306/wjco.124227

Wang JB, Meng Y, He ML, Zhang SJ, Huang XD, Zhang Y, Wu RY, Wang K, Chen XS, Qu Y, Zhang JH, Liu QF, Luo JW, Gao L, Xiao JP, Li YX, Luo LH, Yi JL. Timing matters: Early vs late recurrence in nasopharyngeal carcinoma and its impact on survival. World J Clin Oncol 2026; 17(8): 124227 [DOI: 10.5306/wjco.124227]

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