Cross-sectional survey of factors influencing treatment adherence in elderly cancer patients in rural mountainous Guangyuan, China

Table 5 Multiple linear regression analysis results (dependent variable: 8-item Morisky Medication Adherence Scale total score)

Independent variables	Standardized coefficient (β)	t-value	P value	95%CI
Supportive care needs (n = 103, adjusted R2 = 0.142, F = 4.128, P = 0.001)
Physical and daily living needs	-0.183	-2.456	0.016	-0.942 to -0.100
Health information needs	-0.162	-2.134	0.035	-0.815 to -0.031
Psychological needs	-0.143	-1.987	0.049	-0.768 to -0.002
Care and support needs	-0.102	-1.423	0.158	-0.712 to 0.116
Sexuality needs	-0.052	-0.724	0.471	-0.501 to 0.233
Symptom burden (n = 71-81, adjusted R2 = 0.168, F = 4.782, P < 0.001)
Fatigue severity	-0.254	-3.128	0.002	-0.412 to -0.096
Nausea severity	-0.186	-2.245	0.027	-0.351 to -0.021
Oral mucositis severity	-0.172	-2.078	0.040	-0.337 to -0.007
Vomiting severity	-0.134	-1.618	0.108	-0.298 to 0.030
Diarrhea severity	-0.098	-1.182	0.240	-0.262 to 0.066
Financial toxicity (n = 103, adjusted R2 = 0.243, F = 6.892, P < 0.001)
Direct medical costs	-0.312	-3.456	0.001	-0.498 to -0.126
Indirect medical costs	-0.268	-2.978	0.004	-0.445 to -0.091
Medication costs	-0.234	-2.598	0.011	-0.415 to -0.053
Treatment interruption	-0.198	-2.198	0.030	-0.376 to -0.020
Debt situation	-0.175	-1.943	0.055	-0.354 to 0.004
Psychological status (n = 49, adjusted R2 = 0.268, F = 5.784, P < 0.001)
Social support (SSRS)	0.312	3.102	0.003	0.109-0.515
Anxiety symptoms (HADS-A)	-0.286	-2.845	0.007	-0.489 to -0.083
Depression symptoms (HADS-D)	-0.234	-2.326	0.025	-0.438 to -0.030
Life event impact (DT)	-0.198	-1.968	0.056	-0.402 to 0.006

β is standardized regression coefficient. All models were checked for multicollinearity (all variance inflation factors < 3.0), residual normality (Shapiro-Wilk test P > 0.05), and influential observations (Cook’s distance < 0.5 for all cases). Variable selection used stepwise regression with entry criterion P < 0.10 and removal criterion P > 0.15.

CI: Confidence interval; SSRS: Social Support Rating Scale; HADS-A: Hospital Anxiety and Depression Scale-Anxiety; HADS-D: Hospital Anxiety and Depression Scale-Depression; DT: Distress Thermometer.