Predictive value of peripheral blood systemic immune-inflammation index and blood cell ratio for gastrointestinal polyp burden in patients with Peutz-Jeghers syndrome

Table 3 Optimal cutoff, sensitivity, and specificity determined by the maximum Youden index

Indicator	Cut-off value	Sensitivity (%)	Specificity (%)	AUC (95%CI)	P value
SII	351.9	72.8	87.5	0.765 (0.702-0.828)	< 0.001
NLR	1.78	59.9	87.5	0.739 (0.674-0.804)	< 0.001
PLR	113	78.5	75	0.745 (0.681-0.809)	< 0.001
MLR	0.17	82.8	62.5	0.694 (0.625-0.763)	< 0.001
Number of small intestinal polyps	10	59.4	66.3	0.694 (0.621-0.767)	< 0.001
Diameter of small intestinal polyps (mm)	25	80.3	65.3	0.638 (0.561-0.715)	0.002

SII: Systemic immune-inflammation index; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; MLR: Monocyte-to-lymphocyte ratio; AUC: Area under the curve; CI: Confidence interval.