Multicenter nomogram integrating clinicopathological features for prognosis in stage II-III deficient/microsatellite instability-high rectal cancer

Table 4 Results of the univariate and multivariate Cox regression analysis for recurrence-free survival among the clinical characteristics

Variables	Univariate Cox analysis		Multivariate Cox analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age (years)		0.326
mean ± SD	1.02 (0.98-1.05)
BMI (kg/m2)		0.278
mean ± SD	0.92 (0.80-1.07)
LVI		< 0.001		0.018
Negative	Reference		Reference
Positive	7.34 (3.02-17.86)		3.31 (1.23-8.91)
PNI		0.001		0.305
Negative	Reference		Reference
Positive	5.11 (1.92-13.60)		1.75 (0.60-5.14)
Gender		0.200		0.768
Male	Reference
Female	0.52 (0.19-1.42)		1.19 (0.37-3.87)
AJCC TNM staging system		< 0.001		0.003
II	Reference		Reference
III	8.98 (3.61-22.34)		5.23 (1.75-15.62)
CA19-9 (35 U/mL)		0.582
< 35	Reference
≥ 35	0.71 (0.21-2.42)
CEA (5 ng/mL)		0.765
< 5	Reference
≥ 5	1.16 (0.45-2.98)

HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; LVI: Lymphovascular invasion; PNI: Perineural invasion; AJCC: American Joint Committee on Cancer; TNM: Tumor-node-metastasis; CA19-9: Cancer antigen 19-9; CEA: Carcinoembryonic antigen.