Multicenter nomogram integrating clinicopathological features for prognosis in stage II-III deficient/microsatellite instability-high rectal cancer

Table 3 Relationship between perineural invasion and clinical characteristics, n (%)

Variables		PNI negative (n = 93)	PNI positive (n = 14)	P value
Age (≥ 53 years/< 53 years)		37 (39.8)/56 (60.2)	5 (35.7)/9 (64.3)	1.000
BMI (kg/m2)	mean ± SD	23.0 ± 3.2	23.0 ± 3.2	0.700
Gender (female/male)		37(39.8)/56 (60.2)	0 (0)/14 (100.0)	0.009
CA19-9 (< 35 U/mL/≥ 35 U/mL)	Missing data	77 (82.8)/15 (16.1)/1 (1.1)	10 (71.4)/3 (21.4)/1 (7.1)	0.831
CEA (< 5 ng/mL/≥ 5 ng/mL)	Missing data	68 (73.1)/24 (25.8)/1 (1.1)	9 (64.3)/4 (28.6)/1 (7.1)	0.982
LVI (negative/positive)		77 (82.8)/16 (17.)	7 (50.0)/7 (50.0)	0.015
T stage (1/2/3/4)		1 (1.1)/2(2.2)/78 (83.9)/12 (12.9)	0 (0)/1 (7.1)/9 (64.3)/4 (28.6)	0.283
N stage (0/1/2)		71 (76.3)/14 (15.1)/8 (8.6)	2 (14.3)/8 (57.1)/4 (28.6)	< 0.001
AJCC TNM staging system (II/III)		77 (82.8)/16 (17.2)	6 (42.9)/8 (57.1)	0.003
Recurrence (no/yes)		78 (83.9)/15 (16.1)	8 (57.1)/6 (42.9)	0.047

PNI: Perineural invasion; BMI: Body mass index; CA19-9: Cancer antigen 19-9; CEA: Carcinoembryonic antigen; LVI: Lymphovascular invasion; AJCC: American Joint Committee on Cancer; TNM: Tumor-node-metastasis.