Multicenter nomogram integrating clinicopathological features for prognosis in stage II-III deficient/microsatellite instability-high rectal cancer

Table 2 Relationship between lymphovascular invasion and clinical characteristics, n (%)

Variables		LVI negative (n = 84)	LVI positive (n = 23)	P value
Age (≥ 53 years/< 53 years)		34 (40.5)/50 (59.5)	8 (34.8)/15 (65.2)	0.787
BMI (kg/m2)	mean ± SD	23.1 ± 3.3	55.8 ± 3.3	0.798
Sex (female/male)		29 (34.5)/55 (65.5)	8 (34.8)/15 (65.2)	1.000
CA19-9 (< 35 U/mL/≥ 35 U/mL)	Missing data	70 (83.3)/13 (15.5)/1 (1.2)	17 (73.9)/5 (21.7)/1 (4.3)	0.643
CEA (< 5 ng/mL/≥ 5 ng/mL)	Missing data	61 (72.6)/22 (26.2)/1 (1.2)	16 (69.6)/6 (26.1)/1 (4.3)	1.000
PNI (negative/positive)		77 (91.7)/7 (8.3)	16 (69.6)/7 (30.4)	0.015
T stage (1/2/3/4)		1 (1.2)/1 (1.2)/69 (82.1)/13 (15.5)	0 (0)/2 (8.7)/18 (78.3)/3 (13.0)	0.261
N stage (0/1/2)		64 (76.2)/16 (19.0)/4 (4.8)	9 (39.1)/6 (26.1)/8 (34.8)	< 0.001
AJCC TNM staging system (II/III)		73 (86.9)/11 (13.1)	10 (43.5)/13 (56.5)	< 0.001
Recurrence (no/yes)		76 (90.5)/8 (9.5)	10 (43.5)/13 (56.5)	< 0.001

LVI: Lymphovascular invasion; BMI: Body mass index; CA19-9: Cancer antigen 19-9; CEA: Carcinoembryonic antigen; PNI: Perineural invasion; AJCC: American Joint Committee on Cancer; TNM: Tumor-node-metastasis.