Copper homeostasis imbalance and cuproptosis: Emerging targets and strategies for gastrointestinal tumor therapy

doi:10.5306/wjco.121645

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Jul 24, 2026; 17(7): 121645
Published online Jul 24, 2026. doi: 10.5306/wjco.121645

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Figure 4 Multi-target regulation of cuproptosis by traditional Chinese medicine and natural products. Traditional Chinese medicine-derived compounds and natural products may modulate cuproptosis-related vulnerability through copper binding or transport, mitochondrial metabolic remodeling, reactive oxygen species accumulation, glutathione depletion, and Fe-S cluster destabilization. Representative agents illustrate the multi-component and multi-target potential of natural products in copper-dependent cancer therapy, although direct evidence for canonical cuproptosis remains context-dependent. ROS: Reactive oxygen species; GSH: Glutathione; CTR1: Copper transporter 1; MDR: Multi-drug resistance; DNA: Deoxyribonucleic acid; TCA: Tricarboxylic acid cycle; OXPHOS: Oxidative phosphorylation; TCM: Traditional Chinese medicine.

Citation: Sun ZJ, Wang K, Li JQ, Song LJ, Liang KN, Cao TL, Jiang HZ. Copper homeostasis imbalance and cuproptosis: Emerging targets and strategies for gastrointestinal tumor therapy. World J Clin Oncol 2026; 17(7): 121645
URL: https://www.wjgnet.com/2218-4333/full/v17/i7/121645.htm
DOI: https://dx.doi.org/10.5306/wjco.121645

Sun ZJ, Wang K, Li JQ, Song LJ, Liang KN, Cao TL, Jiang HZ. Copper homeostasis imbalance and cuproptosis: Emerging targets and strategies for gastrointestinal tumor therapy. World J Clin Oncol 2026; 17(7): 121645 [DOI: 10.5306/wjco.121645]

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