Whole-exome sequencing identification of the risk variants in a middle-aged adult with intracranial Ewing’s sarcoma: A case report

doi:10.5306/wjco.121262

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Jul 24, 2026; 17(7): 121262
Published online Jul 24, 2026. doi: 10.5306/wjco.121262

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Figure 3 Biological analysis of risk variants. A and B: Neurofibromin 1 Leu 190 (A) and secreted protein acidic and rich in cysteine (SPARC) Arg 255 (B) across species; C and D: Schematic diagrams of the 3D SPARC protein structure prior to and after C > D mutation, which altered the amino acid at position 255 from an arginine to a histidine.

Citation: Cheng Y, Yu X, Song ZN, Li MJ, Zhao XR, Jia XD, Liu Z, Yu Z, Zhang FY. Whole-exome sequencing identification of the risk variants in a middle-aged adult with intracranial Ewing’s sarcoma: A case report. World J Clin Oncol 2026; 17(7): 121262
URL: https://www.wjgnet.com/2218-4333/full/v17/i7/121262.htm
DOI: https://dx.doi.org/10.5306/wjco.121262

Cheng Y, Yu X, Song ZN, Li MJ, Zhao XR, Jia XD, Liu Z, Yu Z, Zhang FY. Whole-exome sequencing identification of the risk variants in a middle-aged adult with intracranial Ewing’s sarcoma: A case report. World J Clin Oncol 2026; 17(7): 121262 [DOI: 10.5306/wjco.121262]

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