Evolving patterns of gastrointestinal stromal tumor presentation, management, and outcome over three decades: A Middle Eastern retrospective study

doi:10.5306/wjco.120388

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Jun 24, 2026; 17(6): 120388
Published online Jun 24, 2026. doi: 10.5306/wjco.120388

Table 6 Management and outcome of gastrointestinal stromal tumor cases based on temporal stratification, n (%)

	1995-2004 (n = 25)	2005-2014 (n = 96)	2015-2024 (n = 161)	P value
Management
Complete resection with negative surgical margins	21 (84.0)	81 (84.4)	139 (86.3)	0.76 for all
Complete resection with positive surgical margins	4 (16.0)	11 (11.5)	18 (11.2)
Unresectable	0 (0.0)	4 (4.2)	4 (2.5)
CT guided biopsy	0 (0.0)	3 (3.1)	5 (3.1)	0.67
Types of resections
Open	23 (92.0)	68 (76.4)	33 (21.7)	0.001 for all
Laparoscopic resection	2 (8.0)	15 (16.9)	97 (63.8)
Robotic resection	0 (0.0)	6 (6.7)	22 (14.5)
Chemotherapy¹	8 (32.0)	48 (50.0)	89 (55.3)	0.09
Radiation therapy	2 (8.0)	0 (0.0)	1 (0.6)	0.04
Outcome
Disease-free survival	23 (92.0)	69 (71.9)	140 (87.0)	0.01 for all
Survived with recurrent/metastatic disease	0 (0.0)	17 (17.7)	13 (8.1)
Died	2 (8.0)	10 (10.4)	8 (5.0)
Incidental post-sleeve gastrectomy	2 (8.0)	4 (4.2)	19 (11.8)	0.11
Multiple operations	2 (8.0)	2 (2.1)	9 (5.6)	0.30

¹Imatinib.

CT: Computerized tomography.

Full Size Table

Citation: El-Matbouly MA, Al-Thani H, El-Menyar A, Al-Sulaiti M, Asim M, Al Yaseen M, Suliman A, Albahrani A, Al-Bozom I, Tabeb A. Evolving patterns of gastrointestinal stromal tumor presentation, management, and outcome over three decades: A Middle Eastern retrospective study. World J Clin Oncol 2026; 17(6): 120388
URL: https://www.wjgnet.com/2218-4333/full/v17/i6/120388.htm
DOI: https://dx.doi.org/10.5306/wjco.120388

El-Matbouly MA, Al-Thani H, El-Menyar A, Al-Sulaiti M, Asim M, Al Yaseen M, Suliman A, Albahrani A, Al-Bozom I, Tabeb A. Evolving patterns of gastrointestinal stromal tumor presentation, management, and outcome over three decades: A Middle Eastern retrospective study. World J Clin Oncol 2026; 17(6): 120388 [DOI: 10.5306/wjco.120388]

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