Identification of SRSF2 as a potential immunodiagnostic biomarker for osteosarcoma: A study based on focused protein microarray

Figure 3 Serine/arginine-rich splicing factor 2 is overexpressed in osteosarcoma tissue compared with the osteochondroma and normal bone tissue by immunohistochemistry. A and B: Positive staining of serine/arginine-rich splicing factor 2 (SRSF2) expressed in representative osteosarcoma tissue at 100 × and 400 × magnification, respectively; C and D: Weak positive staining of SRSF2 expressed in osteochondroma tissue at 100 × and 400 × magnification, respectively; E and F: Negative staining of SRSF2 expressed in normal bone tissue at 100 × and 400 × magnification, respectively; G: Immunohistochemistry. Scores of SRSF2 between osteosarcoma, osteochondroma, and normal controls. IHC: Immunohistochemistry; SRSF2: Serine/arginine-rich splicing factor 2; OS: Osteosarcoma; OC: Osteochondroma; NC: Normal control.