Identification of SRSF2 as a potential immunodiagnostic biomarker for osteosarcoma: A study based on focused protein microarray

Figure 1 Receiver operator characteristic curve and scatter plots for three anti-tumor associated antigen autoantibodies in the cohort for focused protein microarray. A-C: Analysis of receiver operator characteristic curve with area under the curve and 95% confidence interval; D-F: Serological levels in signal to noise ratio of three anti-tumor associated antigen autoantibodies in osteosarcoma and normal human sera in scatter plots. The longest line means median, and the 25^th percentiles and 75^th percentiles are presented by the shorter line. GNA11: G-protein subunit alpha 11; AUC: Area under the curve; CI: Confidence interval; SRSF2: Serine/arginine-rich splicing factor 2; PIK3CA: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; SNR: Signal to noise ratio; OS: Osteosarcoma; NHS: Normal human sera.