Construction and validation of a multiparameter diagnostic model based on conventional tumor markers and cytokines for lung cancer

doi:10.5306/wjco.v17.i4.119365

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Apr 24, 2026; 17(4): 119365
Published online Apr 24, 2026. doi: 10.5306/wjco.v17.i4.119365

Table 2 Diagnostic value of carcinoembryonic antigen, cytokeratin 19 fragment, neuron-specific enolase, interleukin-8, monocyte chemoattractant protein-1, and tumor necrosis factor-alpha

Indicator	AUC (95%CI)	P value	Cut-off value	Sensitivity (%)	Specificity (%)
CEA	0.755 (0.694-0.816)	< 0.001	2.85	72.6	81.1
CY211	0.703 (0.639-0.767)	< 0.001	2.26	68.1	74.8
NSE	0.587 (0.514-0.661)	0.017	10.10	56.6	67.1
IL-8	0.957 (0.935-0.978)	< 0.001	126.25	93.8	94.4
MCP-1	0.825 (0.772-0.877)	< 0.001	427.64	86.7	88.1
TNF-α	0.936 (0.907-0.965)	< 0.001	9.85	89.4	90.9

AUC: Area under the curve; CEA: Carcinoembryonic antigen; CY211: Cytokeratin 19 fragment; NSE: Neuron-specific enolase; IL: Interleukin; MCP-1: Monocyte chemoattractant protein-1; TNF-α: Tumor necrosis factor-alpha.

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Citation: Zhang YN, Jiang T, Zhang PJ, Wang HJ. Construction and validation of a multiparameter diagnostic model based on conventional tumor markers and cytokines for lung cancer. World J Clin Oncol 2026; 17(4): 119365
URL: https://www.wjgnet.com/2218-4333/full/v17/i4/119365.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i4.119365

Zhang YN, Jiang T, Zhang PJ, Wang HJ. Construction and validation of a multiparameter diagnostic model based on conventional tumor markers and cytokines for lung cancer. World J Clin Oncol 2026; 17(4): 119365 [DOI: 10.5306/wjco.v17.i4.119365]

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