Construction and validation of a multiparameter diagnostic model based on conventional tumor markers and cytokines for lung cancer

doi:10.5306/wjco.v17.i4.119365

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Apr 24, 2026; 17(4): 119365
Published online Apr 24, 2026. doi: 10.5306/wjco.v17.i4.119365

Table 1 Differences in indicator levels between healthy control group and lung cancer group

Indicator	Healthy control group (n = 143)	Lung cancer group (n = 113)
CEA (ng/L)	1.55 (0.98, 2.29)	3.40 (1.69, 8.43)
CY211 (ng/mL)	1.65 (1.22, 2.21)	2.55 (1.76, 3.13)
NSE (ng/mL)	9.46 (8.25, 10.78)	10.79 (8.03, 12.48)
GM-CSF (pg/mL)	0.72 (0.35, 1.75)	1.42 (0.82, 2.50)
IL-10 (pg/mL)	1.98 (1.16, 3.05)	1.11 (0.81, 1.70)
IL-8 (pg/mL)	17.12 (8.40, 38.69)	315.75 (160.44, 523.19)
MCP-1 (pg/mL)	341.11 (258.94, 500.58)	636.03 (506.75, 859.70)
TNF-α (pg/mL)	5.94 (4.62, 7.68)	19.33 (12.77, 30.34)

Data are presented as medians (interquartile ranges: 25^th and 75^th percentiles). CEA: Carcinoembryonic antigen; CY211: Cytokeratin 19 fragment; NSE: Neuron-specific enolase; IL: Interleukin; MCP-1: Monocyte chemoattractant protein-1; TNF-α: Tumor necrosis factor-alpha.

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Citation: Zhang YN, Jiang T, Zhang PJ, Wang HJ. Construction and validation of a multiparameter diagnostic model based on conventional tumor markers and cytokines for lung cancer. World J Clin Oncol 2026; 17(4): 119365
URL: https://www.wjgnet.com/2218-4333/full/v17/i4/119365.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i4.119365

Zhang YN, Jiang T, Zhang PJ, Wang HJ. Construction and validation of a multiparameter diagnostic model based on conventional tumor markers and cytokines for lung cancer. World J Clin Oncol 2026; 17(4): 119365 [DOI: 10.5306/wjco.v17.i4.119365]

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