Current perspectives on diagnosis and management of primary and secondary breast endometriosis and potential risk of breast cancer

doi:10.5306/wjco.v17.i4.118631

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World Journal of Clinical Oncology

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2218-4333

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World J Clin Oncol. Apr 24, 2026; 17(4): 118631
Published online Apr 24, 2026. doi: 10.5306/wjco.v17.i4.118631

Table 2 Immunohistochemical profile

Marker	Expected result	Diagnostic significance
CD10	Positive (stromal cells)	Sensitive marker of endometrial stroma. Useful when glands are scant
PAX8	Positive (glandular epithelium)	Confirms Mullerian epithelial origin
GATA3	Negative	Excludes breast epithelial origin
ER/PR	Often positive	Hormonal responsiveness, nonspecific within breast tissue

CD10: Cluster differentiation, antigen; PAX8: Pair boxed, antigen; GATA3: GATA binding protein 3, transcription factor; ER: Endoplasmatic reticulum; PR: Progesterone receptors.

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Citation: Marneri AG, Pavlidis ET, Stavrati KE, Mouratidou C, Kofinas A, Konstantopoulou I, Pavlidis TE. Current perspectives on diagnosis and management of primary and secondary breast endometriosis and potential risk of breast cancer. World J Clin Oncol 2026; 17(4): 118631
URL: https://www.wjgnet.com/2218-4333/full/v17/i4/118631.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i4.118631

Marneri AG, Pavlidis ET, Stavrati KE, Mouratidou C, Kofinas A, Konstantopoulou I, Pavlidis TE. Current perspectives on diagnosis and management of primary and secondary breast endometriosis and potential risk of breast cancer. World J Clin Oncol 2026; 17(4): 118631 [DOI: 10.5306/wjco.v17.i4.118631]

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