MicroRNAs as diagnostic and prognostic biomarkers in chemotherapy-induced peripheral neuropathy: A systematic review

Table 3 Differentially expressed microRNAs associated with chemotherapy-induced peripheral neuropathy and their predicted target genes and biological pathways

Ref.	miRNAs expression	Target genes	Biological pathways
Davey et al[36], 2023	Let-7a: No difference; miR-21: No difference; miR-145: No difference; miR-155: No difference; miR-195: No difference	N/A	N/A
Ju et al[37], 2022	hsa-miR-885-5p: Downregulation; hsa-miR-378f: Downregulation; hsa-miR-200c-3p: Downregulation; hsa-miR-4666a-3p: Downregulation	ACACA, AKT1, MYRF, NDST1, KCNJ6, P4HB, RAP1B, REST, TGFB2, YY1, TXNL1, IGDCC3, WTAP, HIPK3, ZNF609, PRKD2, RDH11, LGSN, CAB39, SPA17, ARL8B, WDR33, RCC2, CELF4, CYP20A1, ESYT2, CACNG8, DCTPP1, HAUS3, VPS37B, LMNB2, PPARGC1B, DPY19 L3, ARGFX	Peptidyl-serine phosphorylation. Regulation of alternative mRNA splicing. Gastric cancer signaling. Neurotrophin signaling. Mitogen-activated protein kinase signaling. Adenosine monophosphate-activated protein kinase signaling
Łuczkowska et al[39], 2021	miRNA191-5p: Upregulation; miRNA23a-3p: Upregulation; miRNA24-3p: Upregulation; miRNA92: Upregulation; miRNA22: Upregulation	NTRK2, NYAP2, ERBB3, SNAP91, ERBB4, GLDN, NFIB, HIPK1, WNT1, CDX2, CEBPD, TP53INP1, ESR1, EYA3, EZH1, PER1, MECOM	Neuron apoptotic process. Neuron apoptosis. Neuronal stem cell maintenance. Neural tube closure. Regulation of intrinsic apoptotic signaling. Regulation of extrinsic apoptotic signaling. Apoptotic mitochondrial changes
Noda-Narita et al[40], 2020	miR-451a: No difference; miR-6849-5p: No difference; miR-1290: No difference; miR-4476: No difference; miR-204-3p: No difference; miR-23a-3p: No difference; miR-6846-5p: No difference; miR-6870-5p: No difference; miR-5008-5p: No difference; miR-1249-5p: No difference; miR-6806-5p: No difference; miR-4718: No difference; miR-619-5p: No difference; miR-4462: No difference; miR-4539: No difference	N/A	N/A

miRNA: MicroRNA; N/A: Not applicable.