MicroRNAs as diagnostic and prognostic biomarkers in chemotherapy-induced peripheral neuropathy: A systematic review

Table 1 Summary of the main characteristics of the studies selected in the systematic review, mean ± SD/median (range)/n (%)

Ref.	Design	Country	Malignancy type	Number of participants	Age (years)	Gender	Antineoplastic agents	CIPN diagnosis	CIPN/non-CIPN	Sample	miRNAs detection
Davey et al[36], 2023	Prospective cohort	Ireland	Breast cancer	101	55 (25-76)	M: 0 (0%); F: 101 (100%)	Paclitaxel. AC-T (n = 56) TC-H (n = 19) TC-HL (n = 6) other (n = 20)	NCI-CTCAE	34/67	Whole blood	qRT-PCR
Ju et al[37], 2022	Prospective cohort	South Korea	Gastric cancer	32	55.6 ± 11.5	M: 25 (78.1); F: 7 (21.9)	Oxaliplatin (XELOX)	NCI-CTCAE	18/14	Plasma	qRT-PCR
Ju et al[38], 2024	Prospective cohort	South Korea	Colorectal cancer	27	62.4 ± 5.1	M: 14 (51.9); F: 13 (48.1)	Oxaliplatin (FOLFOX)	NCI-CTCAE	15/12	Plasma	qRT-PCR
Łuczkowska et al[39], 2021	Case-control	Poland	Multiple myeloma	60	65.4 ± 8.31	M: 39 (65); F: 21 (35)	Bortezomib. VTD (n = 36) VMP (n = 8) VD (n = 3) VCD (n = 3) VRD (n = 1) RD (n = 10)	NCI-CTCAE	32/28	Plasma	Microarrays technique and qRT-PCR
Noda-Narita et al[40], 2020	Retrospective cohort	Japan	Breast cancer	84	CIPN group: 54 (34-74); non-CIPN group: 46 (27-73)	M: 0 (0); F: 84 (100)	Paclitaxel	NCI-CTCAE	38/46	Plasma	Microarray hybridization

M: Males; F: Females; CIPN: Chemotherapy-induced peripheral neuropathy; miRNA: MicroRNA; AC-T: Doxorubicin and cyclophosphamide followed by paclitaxel; TC-H (L): Docetaxel, carboplatin followed by trastuzumab (and lapatinib); NCI-CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; qRT-PCR: Quantitative reverse transcription polymerase chain reaction; XELOX: Oxaliplatin and capecitabine; FOLFOX: 5-fluorouracil, leucovorin, and oxaliplatin; VTD: Bortezomib, thalidomide, dexamethasone; VMP: Bortezomib, melphalan, prednisone; VD: Bortezomib, dexamethasone; VCD: Bortezomib, cyclophosphamide, dexamethasone; VRD: Lenalidomide, bortezomib, dexamethasone; RD: Lenalidomide, dexamethasone.