Prognostic value of clinicopathological parameters in adenoid cystic carcinoma: A retrospective cohort study

Table 5 Cox proportional hazards regression analysis of prognostic factors in adenoid cystic carcinoma, hazard ratio (95%CI)

Variable	Univariate	P value	Multivariate	P value
Recurrence-free survival
Advanced T stage (T3 and T4 vs T1 and T2)	3.89 (1.21-9.85)	0.021	3.46 (1.21-9.85)	0.021
Positive margins (R1/R2 vs R0)	2.84 (1.09-7.42)	0.032	2.84 (1.09-7.42)	0.032
PNI (present vs absent)	2.67 (1.01-7.09)	0.047	2.12 (0.91-6.03)	0.081
PORT (yes vs no)	0.57 (0.24-1.31)	0.182	0.57 (0.24-1.31)	0.182
Overall survival
Advanced T stage (T3 and T4 vs T1 and T2)	4.12 (1.39-12.20)	0.011	3.28 (1.18-9.11)	0.023
Positive margins (R1/R2 vs R0)	3.01 (1.08-8.39)	0.035	2.71 (1.01-7.29)	0.048
PNI (present vs absent)	2.74 (1.02-7.35)	0.044	2.31 (0.89-6.04)	0.075
PORT (yes vs no)	0.49 (0.21-1.12)	0.094	0.52 (0.24-1.15)	0.096

PNI: Perineural invasion; PORT: Postoperative radiotherapy.