PIGU overexpression and regulation of cellular biological functions in bladder cancer

Figure 13  Relationship between PIGU expression and tumor immune infiltration. A: Gene Ontology enrichment analysis of differentially expressed genes in high- and low-PIGU expression groups; B: Kyoto Encyclopedia of Genes and Genomes enrichment analysis; C: Correlation between PIGU expression and immune cell infiltration levels from the TIMER website; D: Correlation between PIGU expression and stromal score, immune score, ESTIMATE score, and tumor purity; E: Differential expression of 13 immune checkpoint genes in high- and low-PIGU expression groups; F: Correlation scatter plots of PIGU with VTCN1, CD28, CD27, CD70, ICOS, TNFRSF9, and TNFRSF18. ^aP < 0.01, ^bP < 0.001.