Oncologic safety and reproductive outcomes of conservative therapy for early-stage endometrial disease

doi:10.5306/wjco.v17.i3.116062

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Mar 24, 2026; 17(3): 116062
Published online Mar 24, 2026. doi: 10.5306/wjco.v17.i3.116062

Table 3 Multivariable Cox proportional hazards model for recurrence

Variable	HR	95%CI	P value
Age (per year)	0.99	0.90-1.10	0.920
BMI > 30 (vs ≤ 30)	2.95	1.12-7.76	0.029
Diagnosis (G1 EA vs AH)	1.71	0.66-4.44	0.274
PCOS (yes vs no)	1.19	0.45-3.13	0.729
DM (yes vs no)	1.45	0.47-4.46	0.519
HTN (yes vs no)	0.45	0.10-2.07	0.303
Ki-67 > 20% (vs ≤ 20%)	3.12	1.25-7.81	0.015
HE4 > 50 pmol/L (vs ≤ 50)	2.78	1.10-7.02	0.031

HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; PCOS: Polycystic ovary syndrome; DM: Diabetes mellitus; HTN: Hypertension; HE4: Human epididymis protein 4.

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Citation: Jamil A, Sughra G, Abbasi GD, Adane S, Punshi M, Muhammad MG, Nausherwan M, Ishtiaq Y, Hazoor MD. Oncologic safety and reproductive outcomes of conservative therapy for early-stage endometrial disease. World J Clin Oncol 2026; 17(3): 116062
URL: https://www.wjgnet.com/2218-4333/full/v17/i3/116062.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i3.116062

Jamil A, Sughra G, Abbasi GD, Adane S, Punshi M, Muhammad MG, Nausherwan M, Ishtiaq Y, Hazoor MD. Oncologic safety and reproductive outcomes of conservative therapy for early-stage endometrial disease. World J Clin Oncol 2026; 17(3): 116062 [DOI: 10.5306/wjco.v17.i3.116062]

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