Oncologic safety and reproductive outcomes of conservative therapy for early-stage endometrial disease

doi:10.5306/wjco.v17.i3.116062

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World Journal of Clinical Oncology

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2218-4333

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Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Mar 24, 2026; 17(3): 116062
Published online Mar 24, 2026. doi: 10.5306/wjco.v17.i3.116062

Table 2 Oncologic outcomes, n (%)/mean ± SD

Outcome	Overall (n = 234)	AH (n = 126)	G1 EA (n = 108)	OR (95%CI) G1 EA vs AH
CR rate	187 (79.9)	107 (84.9)	80 (74.1)	0.50 (0.27-0.94)
Time to CR (months)	4.0 ± 1.5	3.8 ± 1.4	4.3 ± 1.6	-
Recurrence rate (of CR)	47 (25.1)	19 (17.8)	28 (35.0)	2.51 (1.25-5.04)
Time to recurrence (months)	11.4 ± 4.6	12.5 ± 5.0	10.5 ± 4.2	-
Definitive surgery	56 (23.9)	23 (18.3)	33 (30.6)	1.97 (1.06-3.65)
Occult disease (of surgery)	14 (25.0)	5 (21.7)	9 (27.3)	1.35 (0.39-4.71)
Follow-up (months)	36.3 ± 13.5	38.0 ± 14.0	34.2 ± 12.8	-
DSS	232 (99.1)	126 (100.0)	106 (98.1)	3.59 (0.14-90.37)
OS	232 (99.1)	126 (100.0)	106 (98.1)	3.59 (0.14-90.37)

AH: Atypical hyperplasia; G1 EA: Grade 1 endometrioid adenocarcinoma; OR: Odds ratio; OS: Overall survival; CI: Confidence interval; CR: Complete response; DSS: Disease-specific survival.

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Citation: Jamil A, Sughra G, Abbasi GD, Adane S, Punshi M, Muhammad MG, Nausherwan M, Ishtiaq Y, Hazoor MD. Oncologic safety and reproductive outcomes of conservative therapy for early-stage endometrial disease. World J Clin Oncol 2026; 17(3): 116062
URL: https://www.wjgnet.com/2218-4333/full/v17/i3/116062.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i3.116062

Jamil A, Sughra G, Abbasi GD, Adane S, Punshi M, Muhammad MG, Nausherwan M, Ishtiaq Y, Hazoor MD. Oncologic safety and reproductive outcomes of conservative therapy for early-stage endometrial disease. World J Clin Oncol 2026; 17(3): 116062 [DOI: 10.5306/wjco.v17.i3.116062]

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