When to operate pancreatic intraductal papillary mucinous neoplasm: Literature review

Table 2 It summarizes the differential diagnosis of intraductal papillary mucinous neoplasms

Intraductal oncocytic papillary neoplasm	Intraductal tubulopapillary neoplasm	Mucinous cystic neoplasm	Pancreatic intraepithelial neoplasia	Simple mucinous cyst	Retention cyst
Variable sizes. Arborizing lined by oncocytic cells. It has a different molecular genetic alteration in one of the following genes, ARHGAP26, ASXL1, EPHA8 and ERBB4. DNAJB1-PRKACA fusions. MUC1 and MUC6 positivity	Variable sizes subtype originating from peribiliary cysts. Tributary epithelial cells forming papillary and tubular patterns. High-grade dysplasia solid growth with necrotic foci, little or invisible mucin with intracytoplasmic mucin is present. No mutations in KRAS2 positivity for MUC1+, MUC6+ and negativity for MUC2-	Variable sizes. This cyst is lined by epithelial mucinous layer and stroma of ovarian type. No anatomical communication with pancreatic duct or its branches radiologically	Occult mass. Detected microscopically. Epithelial differentiation towards gastric foveolar epithelium	> 1 cm. Flat epithelium (differentiated towards gastric mucinous type). No papillae. Little atypia	> 1 cm. Simple flat epithelial lining. No papillae. Little atypia