Correlation between bariatric surgery and breast cancer risk in women: A systematic review and meta-analysis

doi:10.5306/wjco.v17.i3.114774

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Mar 24, 2026; 17(3): 114774
Published online Mar 24, 2026. doi: 10.5306/wjco.v17.i3.114774

Table 2 Characteristics of breast cancer in surgical and non-surgical groups, n (%)

Ref.	Arm	Incident breast cancer	Stage at diagnosis	ER+ breast cancer	PR+ breast cancer	HER2+ breast cancer
Doumouras et al[28], 2022	Surgery	99 (0.79)¹	Stage 1: 59 (66.3)	ER+: 47 (64.8)	PR+: 43 (59.1)	HER2+: 6 (8.0)
			Stage 2: 24 (27)	ER-: 6 (9.1)	PR-: 10 (14.8)	HER2-: 46 (63.6)
			Stage 3 and 4: 6 (6.7)	Unknown: 22 (26.1)	Unknown: 22 (26.1)	Unknown: 23 (28.4)
	Control	133 (1.09)¹	Stage 1: 69 (60.5)	ER+: 54 (61.8)	PR+: 47 (54.5)	HER2+: 12 (12.2)
			Stage 2: 35 (30.7)	ER-: 7 (8.1)	PR-: 14 (15.4)	HER2-: 44 (51.2)
			Stage 3 and 4: 10 (8.8)	Unknown: 35 (30.1)	Unknown: 35 (30.1)	Unknown: 40 (36.6)
	P value		0.423	0.045	0.041	0.012
Feigelson et al[24], 2020	Surgery	133 (0.7)	Stage 0: 32 (24.1)	ER+: 111 (83.5)	PR+: 98 (73.7)
			Stage 1: 58 (43.6)	ER-: 19 (14.3)	PR-: 19 (14.3)
			Stage 2: 36 (27.1)	Unknown: 3 (2.2)	Unknown: 16 (12.0)
			Stage 3 and 4: 7 (5.3)
	Control	567 (1.1)	Stage 0: 120 (21.2)	ER+: 453 (79.9)	PR+: 380 (67.0)
			Stage 1: 211 (37.2)	ER-: 91 (16.0)	PR-: 89 (15.7)
			Stage 2: 164 (28.9)	Unknown: 23 (4.1)	Unknown: 98 (17.3)
			Stage 3 and 4: 67 (11.8)
	P value		0.20	0.60	0.60
Hassinger et al[35], 2019	Surgery	17 (0.7)	Stage 0: 2/11 (18.2)	ER+: 4/11 (36.4)	PR+: 5/11 (45.5)	HER2+: 3/11 (27.3)
			Stage 1: 7/11 (63.6)	ER-: 7/11 (63.6)	PR-: 6/11 (54.5)	HER2-: 8/11 (72.7)
			Stage 2: 2/11 (18.2)
			Stage 3 and 4: 0 (0)
	Control	32 (1.3)	Stage 0: 7/29 (24.1)	ER+: 22/31 (71.0)	PR+: 22/31 (71.0)	HER2+: 2/31 (6.5)
			Stage 1: 12/29 (41.4)	ER-: 9/31 (29.0)	PR-: 9/31 (29.0)	HER2-: 29/31 (93.5)
			Stage 2: 7/29 (24.1)
			Stage 3 and 4: 3/29 (10.4)
	P value		0.53	0.04	0.13	0.07
Doumouras et al[36], 2023	Surgery	103 (0.74)	Stage 1: 273 (55.4)	ER+: 48/76 (63.2)	PR+: 43/76 (56.6)	HER2+: 6/76 (7.9)
			Stage 2: 156 (31.6)	ER-: 5/76 (6.5)	PR-: 10/76 (13.2)	HER2-: 46/76 (60.5)
			Stage 3 and 4: 64 (13.0)	Unknown: 23/76 (30.3)	Unknown: 23 (30.3)	Unknown: 24/76 (31.6)
	Control	556 (1.00)	Stage 1: 60 (67.4)	ER+: 232/406 (57.1)	PR+: 207/406 (51.0)	HER2+: 52/406 (12.8)
			Stage 2: 24 (27.0)	ER-: 48/406 (11.8)	PR-: 73/406 (18.0)	HER2-: 221/406 (54.4)
			Stage 3 and 4: 5 (5.6)	Unknown: 126/406 (31.0)	Unknown: 126/406 (31.0)	Unknown: 133/406 (32.8)
	P value	0.29	0.94	0.9	0.65

¹After a 1-year lag period.

Descriptive tumor characteristics are not available for all breast cancer patients. ER: Estrogen receptor; PR: Progesterone receptor; HER2: Human epidermal growth factor receptor 2.

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Citation: He YF, Wang HZ, Bian N, Hu XD, He QT, Liu JQ, Li HM, Lu SF, Wu N. Correlation between bariatric surgery and breast cancer risk in women: A systematic review and meta-analysis. World J Clin Oncol 2026; 17(3): 114774
URL: https://www.wjgnet.com/2218-4333/full/v17/i3/114774.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i3.114774

He YF, Wang HZ, Bian N, Hu XD, He QT, Liu JQ, Li HM, Lu SF, Wu N. Correlation between bariatric surgery and breast cancer risk in women: A systematic review and meta-analysis. World J Clin Oncol 2026; 17(3): 114774 [DOI: 10.5306/wjco.v17.i3.114774]

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