T cell exhaustion markers in hepatitis C virus-related hepatocellular carcinoma: Expression patterns and prognostic significance in an Egyptian cohort

Figure 7 Receiver operating characteristic curves for hepatocellular carcinoma Mortality Prediction (random forest and logistic regression). Receiver operating characteristic curves for CD4/programmed death 1 [solid blue line, area under the curve (AUC) = 0.92, 95% confidence interval (CI): 0.85-0.98, cut-off > 35%, sensitivity 88%, specificity 85%], CD8/T cell immunoglobulin and mucin domain-containing protein 3 (dotted green line, AUC = 0.90, 95%CI: 0.83-0.97, cut-off > 17%, sensitivity 85%, specificity 82%), and alpha-fetoprotein + CD8/T cell immunoglobulin and mucin domain-containing protein (dashed orange line, AUC = 0.95, 95%CI: 0.90-0.99, cut-off alpha-fetoprotein > 13000 ng/mL and CD8/T cell immunoglobulin and mucin domain-containing protein > 17%, sensitivity 92%, specificity 90%) in predicting hepatocellular carcinoma mortality. ROC: Receiver operating characteristic; HCC: Hepatocellular carcinoma; PD-1: Programmed death 1; AUC: Area under the curve; CI: Confidence interval; AUC: Area under the curve; TIM3: T cell immunoglobulin and mucin domain-containing protein; AFP: Alpha-fetoprotein; Sens: Sensitivity; Spec: Specificity.