T cell exhaustion markers in hepatitis C virus-related hepatocellular carcinoma: Expression patterns and prognostic significance in an Egyptian cohort

Figure 6 Receiver operating characteristic curves for CD4/programmed death 1 and alpha-fetoprotein in predicting hepatocellular carcinoma mortality. Receiver operating characteristic curves for CD4/programmed death 1 (solid line, area under the curve = 0.92, 95% confidence interval: 0.85-0.98, cut-off > 35%, sensitivity 88%, specificity 85%) and alpha-fetoprotein (dashed line, area under the curve = 0.89, 95% confidence interval: 0.81-0.96, cut-off > 13000 ng/mL, sensitivity 90%, specificity 80%) in predicting hepatocellular carcinoma mortality. ROC: Receiver operating characteristic; PD-1: Programmed death 1; AFP: Alpha-fetoprotein; HCC: Hepatocellular carcinoma; AUC: Area under the curve; CI: Confidence interval; Sens: Sensitivity; Spec: Specificity.