T cell exhaustion markers in hepatitis C virus-related hepatocellular carcinoma: Expression patterns and prognostic significance in an Egyptian cohort

Figure 2 Box plots of immune checkpoint expression across study groups. Box plots of immune checkpoint expression (CD4/programmed death 1, CD8/programmed death 1, CD4/T-cell immunoglobulin and ITIM domain, CD8/T-cell immunoglobulin and ITIM domain, CD4/T cell immunoglobulin and mucin domain-containing protein 3, CD8/T cell immunoglobulin and mucin domain-containing protein 3) and alpha-fetoprotein (AFP) in hepatocellular carcinoma (n = 50), cirrhosis (n = 50), hepatitis C virus (n = 50), and control (n = 50) groups. Boxes represent interquartile ranges, whiskers show range, and horizontal lines indicate medians (AFP) or means (immune markers). P-values from ANOVA (immune markers) and Kruskal-Wallis (AFP) indicate significant differences. AFP: Alpha-fetoprotein; PD-1: Programmed death 1; TIGIT: T-cell immunoglobulin and ITIM domain; TIM-3: T cell immunoglobulin and mucin domain-containing protein 3.