T cell exhaustion markers in hepatitis C virus-related hepatocellular carcinoma: Expression patterns and prognostic significance in an Egyptian cohort

doi:10.5306/wjco.v17.i2.114622

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Feb 24, 2026; 17(2): 114622
Published online Feb 24, 2026. doi: 10.5306/wjco.v17.i2.114622

Table 9 Cox regression analysis for hepatocellular carcinoma mortality

Variable	HR (95%CI)	P value
CD8/TIM3 (high)	2.8 (1.5-5.2)	0.001^a
BCLC stage D	3.1 (1.7-5.6)	< 0.001^b
Age	1.2 (0.9-1.6)	0.15
MELD score	1.1 (0.8-1.5)	0.22

^aP < 0.01.

^bP < 0.001.

IM-3: T cell immunoglobulin and mucin domain-containing protein 3; BCLC: Barcelona Clinic Liver Cancer; MELD: Model for End-Stage Liver Disease; HR: Hazard ratio; CI: Confidence interval.

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Citation: Hasan AM, Ghanem SMFI, Othman AAA, Rashad MH, Nosair N, Elgamal R. T cell exhaustion markers in hepatitis C virus-related hepatocellular carcinoma: Expression patterns and prognostic significance in an Egyptian cohort. World J Clin Oncol 2026; 17(2): 114622
URL: https://www.wjgnet.com/2218-4333/full/v17/i2/114622.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i2.114622

Hasan AM, Ghanem SMFI, Othman AAA, Rashad MH, Nosair N, Elgamal R. T cell exhaustion markers in hepatitis C virus-related hepatocellular carcinoma: Expression patterns and prognostic significance in an Egyptian cohort. World J Clin Oncol 2026; 17(2): 114622 [PMID: 41810349 DOI: 10.5306/wjco.v17.i2.114622]

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