Gene and cytokine expression profiles of metastatic colorectal cancer patients post reovirus administration

Figure 4 Upregulation of AKT1, NFKBIA, and interleukin-6 are correlated with increased signal transducer and activator of transcription 3 expression. A: The relative change AKT1, NFKBIA, and signal transducer and activator of transcription 3 (STAT3) expression (by delta-delta cycle threshold calculations) over time. Statistically significant increases were observed in AKT1 on day 2 (P = 0.004); NFKBIA on days 2 (P = 0.004) and 8 (P = 0.03); and STAT3 on days 8 (P = 0.008) and 15 (P = 0.05). Error bars represent one standard error of the mean of the data; B: The relative change in interleukin-6 expression (by mean expression across all reovirus-treated patients) over time. Statistically significant increases were observed for interleukin-6 on day 8 (P = 0.0001). Error bars represent one standard error of the mean of the data. IL: Interleukin; STAT3: Signal transducer and activator of transcription 3.