Gene and cytokine expression profiles of metastatic colorectal cancer patients post reovirus administration

Figure 1 The expression of 17 significantly altered cytokines relative to pre-values (by mean expression across all reovirus-treated patients) over time. Statistically significant increases were observed for interferon gamma and interleukin-6 during the 15-day period. Statistically significant decreases as compared to baseline were observed for vascular endothelial growth factor, interleukin-8, and regulated upon activation, normal T-cell expressed and secreted during the 15-day period. GM-CSF: Granulocyte-macrophage colony-stimulating factor; IFN: Interferon; IL: Interleukin; MCP: Monocyte chemoattractant protein; MIP: Macrophage inflammatory proteins; RANTES: Regulated upon activation, normal T-cell expressed and secreted; VEGF: Vascular endothelial growth factor.