Characterization of the cellular and transcriptomic landscapes of natural killer cells in hematopoietic microenvironment of myelodysplastic syndrome

Figure 5 differentially expressed gene-based bioprocesses and somatic variations between expanded myelodysplastic syndrome natural killers and expanded healthy donor natural killers. A and B: GOBP (short for gene ontology biological process) analysis (A) and KEGG (short for Kyoto encyclopedia of genes and genomes) signaling pathway analysis (B) of the differentially expressed genes between expanded myelodysplastic syndrome natural killers and expanded healthy donor natural killers according to the website (https://www.kegg.jp/); C: GSEA (short for gene set enrichment analysis) showed the enriched gene sets involved in the indicated bioprocesses; D and E: The distribution of genes with the indicated somatic variations, including variable shear events (D) and differentially variable shear events (E); F: Circos diagrams showed the distribution of genes with somatic variations in chromosomes of expanded myelodysplastic syndrome natural killers and expanded healthy donor natural killers. MDS-NKs: Myelodysplastic syndrome natural killers; HD-NKs: Healthy donor natural killers; GOBP: Short for gene ontology biological process; KEGG: Short for Kyoto encyclopedia of genes and genomes; NES: Normalized enrichment score; FDR: False discovery rate.