Integrated single-cell transcriptomic analysis of brain and lymph node metastases in non-small cell lung cancer

doi:10.5306/wjco.126162

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Oct 24, 2026; 17(10): 126162
Published online Oct 24, 2026. doi: 10.5306/wjco.126162

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Figure 6 Multiplex immunohistochemistry validation and prognostic value of tumor subpopulations. A: Multivariate Cox regression analysis of prognostic factors. Forest plot showing hazard ratio and P values for overall survival of lung adenocarcinoma patients from The Cancer Genome Atlas; B: Representative multiplex immunohistochemistry images showing the expression and spatial distribution of CD68⁺/CD163⁺, PD-1⁺/ CD8⁺, XBP1⁺/ATF6⁺/ATF4⁺ makers in Mets0 and Mets1 non-small cell lung cancer tissues. Scale bars: 50 μm; C: Comparison of positive cell density between Mets0 and Mets1 cancer regions; D: Comparison of positive cell rates between Mets0 and Mets1 cancer regions. Mets0 (n = 11) and Mets1 (n = 12); statistical significance was determined using Mann-Whitney U test; NS indicates not significant.

Citation: Liu ZN, Li MM, Ping Y, Zhao QT, Wang LP, Zhang Y. Integrated single-cell transcriptomic analysis of brain and lymph node metastases in non-small cell lung cancer. World J Clin Oncol 2026; 17(10): 126162
URL: https://www.wjgnet.com/2218-4333/full/v17/i10/126162.htm
DOI: https://dx.doi.org/10.5306/wjco.126162

Liu ZN, Li MM, Ping Y, Zhao QT, Wang LP, Zhang Y. Integrated single-cell transcriptomic analysis of brain and lymph node metastases in non-small cell lung cancer. World J Clin Oncol 2026; 17(10): 126162 [DOI: 10.5306/wjco.126162]

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