Integrated single-cell transcriptomic analysis of brain and lymph node metastases in non-small cell lung cancer

Figure 3 Upregulation of unfolded protein response and associated metabolic pathways in brain and lymph node metastases of non-small cell lung cancer. A: Volcano plot showing differentially expressed genes (DEGs) between brain metastases (mBrain) and primary lung tumors. Red dots (UP) indicate significantly upregulated genes, blue dots (DOWN) indicate downregulated genes, and gray dots (NOT) represent non-significant changes; B: Gene Ontology (GO) enrichment analysis of DEGs in mBrain compared to primary tumors; C: KEGG pathway enrichment analysis of DEGs in mBrain compared to primary tumors; D: Volcano plot showing DEGs between mLN and primary lung tumors. Red dots (UP) indicate significantly upregulated genes, blue dots (DOWN) indicate downregulated genes, and gray dots (NOT) represent non-significant changes; E: GO enrichment analysis of DEGs in mLN compared to primary tumors; F: KEGG pathway enrichment analysis of DEGs in mLN compared to primary tumors.