Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer

doi:10.5306/wjco.125453

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Oct 24, 2026; 17(10): 125453
Published online Oct 24, 2026. doi: 10.5306/wjco.125453

Table 8 Model selection and comparison statistics

Model specification	Log-likelihood	AIC (lower is better)	Model χ²	P value
Univariate (cagA)	-207.67	423.33	3.30	0.069
Toxigenic axis (cagA + vacA)	-207.17	424.34	4.29	0.117
Full multivariate panel	-181.50	377.01	55.63	< 0.001^b

^bP < 0.01.

AIC: Akaike information criterion; cagA: Cytotoxin-associated gene A; vacA: Vacuolating cytotoxin A.

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Citation: Mbuthia O, Mahjabeen I, Kayani M, Mehmood A, Obiero J, Matsumoto T, Bosire K, Mureithi M. Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer. World J Clin Oncol 2026; 17(10): 125453
URL: https://www.wjgnet.com/2218-4333/full/v17/i10/125453.htm
DOI: https://dx.doi.org/10.5306/wjco.125453

Mbuthia O, Mahjabeen I, Kayani M, Mehmood A, Obiero J, Matsumoto T, Bosire K, Mureithi M. Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer. World J Clin Oncol 2026; 17(10): 125453 [DOI: 10.5306/wjco.125453]

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