Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer

doi:10.5306/wjco.125453

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World Journal of Clinical Oncology

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2218-4333

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World J Clin Oncol. Oct 24, 2026; 17(10): 125453
Published online Oct 24, 2026. doi: 10.5306/wjco.125453

Table 7 Multivariate ordinal logistic regression parameter estimates (n = 159)

Predictor/threshold	(β)	Std. Error	z-statistic	P value	OR	95%CI
babA	-0.624	0.107	-5.814	< 0.001^b	0.536	0.428-0.654
iceA	-0.221	0.085	-2.585	0.010^a	0.802	0.675-0.945
cagA	0.073	0.047	1.544	0.123	1.076	0.981-1.182
vacA	0.009	0.091	0.095	0.924	1.009	0.843-1.205
Stage I\|II	-2.368	0.441	-5.376	< 0.001^b	-	-
Stage II\|III	-0.472	0.393	-1.201	0.230	-	-
Stage III\|IV	0.176	0.389	0.452	0.651	-	-

^aP < 0.05.

^bP < 0.01.

cagA: Cytotoxin-associated gene A; vacA: Vacuolating cytotoxin A; babA: Blood group antigen-binding adhesin A; iceA: Induced by contact with epithelium gene A; OR: Odds ratio.

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Citation: Mbuthia O, Mahjabeen I, Kayani M, Mehmood A, Obiero J, Matsumoto T, Bosire K, Mureithi M. Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer. World J Clin Oncol 2026; 17(10): 125453
URL: https://www.wjgnet.com/2218-4333/full/v17/i10/125453.htm
DOI: https://dx.doi.org/10.5306/wjco.125453

Mbuthia O, Mahjabeen I, Kayani M, Mehmood A, Obiero J, Matsumoto T, Bosire K, Mureithi M. Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer. World J Clin Oncol 2026; 17(10): 125453 [DOI: 10.5306/wjco.125453]

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