Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer

doi:10.5306/wjco.125453

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World Journal of Clinical Oncology

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2218-4333

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World J Clin Oncol. Oct 24, 2026; 17(10): 125453
Published online Oct 24, 2026. doi: 10.5306/wjco.125453

Table 5 Relative mRNA expression of Helicobacter pylori virulence factors by tumor-node-metastasis stage (n = 159)

Virulence gene	Stage I median (IQR)	Stage II median (IQR)	Stage III median (IQR)	Stage IV median (IQR)	P value
cagA	1.93 (1.04-3.36)	3.20 (1.51-5.98)	3.80 (1.57-6.49)	3.11 (1.09-6.20)	< 0.001^b
vacA	2.06 (1.36-3.48)	2.42 (1.41-3.92)	3.13 (1.85-3.91)	1.79 (1.12-3.20)	< 0.001^b
babA	4.11 (1.62-5.41)	1.39 (1.03-2.11)	0.57 (0.30-1.11)	1.19 (0.54-1.72)	< 0.001^b
iceA	0.63 (0.39-0.94)	0.86 (0.46-3.17)	0.54 (0.40-0.91)	0.65 (0.30-1.41)	0.027^a

^aP < 0.05.

^bP < 0.01; the Kruskal-Wallis test was used for comparisons across the four stages. cagA: Cytotoxin-associated gene A; vacA: Vacuolating cytotoxin A; babA: Blood group antigen-binding adhesin A; iceA: Induced by contact with epithelium gene A; IQR: Interquartile range.

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Citation: Mbuthia O, Mahjabeen I, Kayani M, Mehmood A, Obiero J, Matsumoto T, Bosire K, Mureithi M. Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer. World J Clin Oncol 2026; 17(10): 125453
URL: https://www.wjgnet.com/2218-4333/full/v17/i10/125453.htm
DOI: https://dx.doi.org/10.5306/wjco.125453

Mbuthia O, Mahjabeen I, Kayani M, Mehmood A, Obiero J, Matsumoto T, Bosire K, Mureithi M. Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer. World J Clin Oncol 2026; 17(10): 125453 [DOI: 10.5306/wjco.125453]

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