Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer

doi:10.5306/wjco.125453

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World Journal of Clinical Oncology

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2218-4333

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Oct 24, 2026; 17(10): 125453
Published online Oct 24, 2026. doi: 10.5306/wjco.125453

Table 3 Distribution of virulence factor accumulation by clinical stage, n (%)

Virulence factor accumulation	Stage I (n = 50)	Stage II (n = 54)	Stage III (n = 18)	Stage IV (n = 37)	P value
1 gene	5 (10.0)	2 (3.7)	0 (0.0)	5 (13.5)
2 genes	5 (10.0)	4 (7.4)	5 (27.8)	8 (21.6)
3 genes	34 (68.0)	36 (66.7)	13 (72.2)	19 (51.4)
4 genes	6 (12.0)	12 (22.2)	0 (0.0)	5 (13.5)	0.045^a

^aP < 0.05.

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Citation: Mbuthia O, Mahjabeen I, Kayani M, Mehmood A, Obiero J, Matsumoto T, Bosire K, Mureithi M. Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer. World J Clin Oncol 2026; 17(10): 125453
URL: https://www.wjgnet.com/2218-4333/full/v17/i10/125453.htm
DOI: https://dx.doi.org/10.5306/wjco.125453

Mbuthia O, Mahjabeen I, Kayani M, Mehmood A, Obiero J, Matsumoto T, Bosire K, Mureithi M. Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer. World J Clin Oncol 2026; 17(10): 125453 [DOI: 10.5306/wjco.125453]

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