Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer

doi:10.5306/wjco.125453

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World Journal of Clinical Oncology

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2218-4333

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Oct 24, 2026; 17(10): 125453
Published online Oct 24, 2026. doi: 10.5306/wjco.125453

Table 2 Prevalence and association of Helicobacter pylori virulence markers, n (%)

Marker	Gastric cancer positive (n = 159)	Controls (n = 200)	Odds ratio	95%CI	P value
cagA	131 (82.4)	40 (20.0)	18.7	10.9-32.3	< 0.001^b
vacA	148 (93.1)	74 (37.0)	22.9	11.6-45.2	< 0.001^b
babA	117 (73.6)	33 (16.5)	14.1	8.6-23.2	< 0.001^b
iceA	58 (36.5)	32 (16.0)	3.01	1.84-4.94	< 0.001^b

^bP < 0.01.

cagA: Cytotoxin-associated gene A; vacA: Vacuolating cytotoxin A; babA: Blood group antigen-binding adhesin A; iceA: Induced by contact with epithelium gene A.

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Citation: Mbuthia O, Mahjabeen I, Kayani M, Mehmood A, Obiero J, Matsumoto T, Bosire K, Mureithi M. Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer. World J Clin Oncol 2026; 17(10): 125453
URL: https://www.wjgnet.com/2218-4333/full/v17/i10/125453.htm
DOI: https://dx.doi.org/10.5306/wjco.125453

Mbuthia O, Mahjabeen I, Kayani M, Mehmood A, Obiero J, Matsumoto T, Bosire K, Mureithi M. Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer. World J Clin Oncol 2026; 17(10): 125453 [DOI: 10.5306/wjco.125453]

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