Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer

doi:10.5306/wjco.125453

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World Journal of Clinical Oncology

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2218-4333

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World J Clin Oncol. Oct 24, 2026; 17(10): 125453
Published online Oct 24, 2026. doi: 10.5306/wjco.125453

Table 1 Baseline demographics and significant clinical characteristics (n = 200), n (%)

Variable	Overall (n = 200)	Stage I (n = 68)	Stage II (n = 65)	Stage III (n = 22)	Stage IV (n = 45)	P value
Age (years)	52.9 ± 16.4	51.2 ± 15.4	54.3 ± 19.3	56.1 ± 12.4	52.0 ± 15.0	0.532
Gender						0.727
Female	88 (44.0)	27 (39.7)	32 (49.2)	10 (45.5)	19 (42.2)
Male	112 (56.0)	41 (60.3)	33 (50.8)	12 (54.5)	26 (57.8)
Histological Dx						0.034^a
Adenocarcinoma	129 (64.5)	43 (63.2)	38 (58.5)	20 (90.9)	28 (62.2)
Others	71 (35.5)	25 (36.8)	27 (41.5)	2 (9.1)	17 (37.8)
Histological grade						0.001^b
Well	47 (23.5)	14 (20.6)	18 (27.7)	6 (27.3)	9 (20.0)
Moderate	48 (24.0)	13 (19.1)	14 (21.5)	5 (22.7)	16 (35.6)
Poorly	47 (23.5)	9 (13.2)	14 (21.5)	10 (45.5)	14 (31.1)
Atypical	58 (29.0)	32 (47.1)	19 (29.2)	1 (4.5)	6 (13.3)
H. pylori (histology)						0.042^a
Positive	130 (65.0)	36 (52.9)	48 (73.8)	17 (77.3)	29 (64.4)
Negative	70 (35.0)	32 (47.1)	17 (26.2)	5 (22.7)	16 (35.6)
Survival status						< 0.001^b
Deceased	65 (32.5)	15 (22.1)	17 (26.2)	10 (45.5)	23 (51.1)
Under treatment	82 (41.0)	15 (22.1)	36 (55.4)	11 (50.0)	20 (44.4)
Cured	53 (26.5)	38 (55.9)	12 (18.5)	1 (4.5)	2 (4.4)

^aP < 0.05.

^bP < 0.01. One-way ANOVA was used to calculate P values for the continuous variable (age), whereas the χ² test or Fisher’s exact test, as appropriate, was used for categorical variables. H. pylori: Helicobacter pylori.

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Citation: Mbuthia O, Mahjabeen I, Kayani M, Mehmood A, Obiero J, Matsumoto T, Bosire K, Mureithi M. Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer. World J Clin Oncol 2026; 17(10): 125453
URL: https://www.wjgnet.com/2218-4333/full/v17/i10/125453.htm
DOI: https://dx.doi.org/10.5306/wjco.125453

Mbuthia O, Mahjabeen I, Kayani M, Mehmood A, Obiero J, Matsumoto T, Bosire K, Mureithi M. Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer. World J Clin Oncol 2026; 17(10): 125453 [DOI: 10.5306/wjco.125453]

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