Clinicopathological, immunohistochemical, and overall-survival associations of poorly cohesive gastric carcinoma stratified by signet ring cell percentage

doi:10.5306/wjco.125097

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Oct 24, 2026; 17(10): 125097
Published online Oct 24, 2026. doi: 10.5306/wjco.125097

Table 4 Immunohistochemical characteristics of defined subtypes within poorly cohesive carcinoma

	Evaluable cases		SRC	SRC/PCC-NOS	PCC-NOS	P value
n			70	171	133
CEA, n/N (%)	209	-	6/42 (14.3)	5/89 (5.6)	6/78 (7.7)	0.416
		-/+	4/42 (9.5)	7/89 (7.9)	6/78 (7.7)
		+	26/42 (61.9)	72/89 (80.9)	61/78 (78.2)
		++	1/42 (2.4)	2/89 (2.2)	1/78 (1.3)
		+++	5/42 (11.9)	3/89 (3.4)	4/78 (5.1)
Ki67, mean (SD)	355		0.40 (0.24)	0.52 (0.22)	0.55 (0.20)	< 0.001
HER2, n/N (%)	350	-	44/62 (71.0)	106/162 (65.4)	82/126 (65.1)	0.122
		+	14/62 (22.6)	42/162 (25.9)	25/126 (19.8)
		++	2/62 (3.2)	11/162 (6.8)	18/126 (14.3)
		+++	2/62 (3.2)	3/162 (1.9)	1/126 (0.8)
P53, n/N (%)	260	-	12/47 (25.5)	33/113 (29.2)	26/100 (26.0)	0.244
		-/+	3/47 (6.4)	9/113 (8.0)	2/100 (2.0)
		+	16/47 (34.0)	33/113 (29.2)	23/100 (23.0)
		++	5/47 (10.6)	11/113 (9.7)	10/100 (10.0)
		+++	11/47 (23.4)	27/113 (23.9)	39/100 (39.0)
EGFR, n/N (%)	111	-	3/18 (16.7)	13/45 (28.9)	9/48 (18.8)	0.545
		-/+	1/18 (5.6)	4/45 (8.9)	2/48 (4.2)
		+	14/18 (77.8)	28/45 (62.2)	37/48 (77.1)
MLH1, n/N (%)	63	-	0/7 (0.0)	0/32 (0.0)	4/24 (16.7)	0.031
MLH1, n/N (%)	63	+	7/7 (100.0)	32/32 (100.0)	20/24 (83.3)
MSH2, n/N (%)	63	+	7/7 (100.0)	32/32 (100.0)	24/24 (100.0)
MSH6, n/N (%)	63	-	0/7 (0.0)	0/32 (0.0)	1/24 (4.2)	0.438
MSH6, n/N (%)	63	+	7/7 (100.0)	32/32 (100.0)	23/24 (95.8)
PMS2, n/N (%)	63	-	0/7 (0.0)	0/32 (0.0)	4/24 (16.7)	0.031
PMS2, n/N (%)	63	+	7/7 (100.0)	32/32 (100.0)	20/24 (83.3)
PD-1, n/N (%)	38	-	6/6 (100.0)	13/15 (86.7)	14/17 (82.4)	0.546
PD-1, n/N (%)	38	+	0/6 (0.0)	2/15 (13.3)	3/17 (17.6)
PD-L1, n/N (%)	171	CPS < 1	21/23 (91.3)	68/78 (87.2)	51/70 (72.9)	0.035
PD-L1, n/N (%)	171	CPS ≥ 1	2/23 (8.7)	10/78 (12.8)	19/7 (27.1)

Data are presented as n/N (%), where N represents the number of evaluable cases within each subtype group. Immunohistochemistry markers were not available for all patients; analyses based on evaluable cases were exploratory. SRC: Signet ring carcinoma; PCC-NOS: Poorly cohesive carcinoma-not otherwise specified; CEA: Carcinoembryonic antigen; EGFR: Epidermal growth factor receptor; MLH1: MutL homolog 1; MSH: MutS homolog; PMS2: Postmeiotic segregation increased 2; PD-1: Programmed death protein 1; PD-L1: Programmed death protein ligand 1; CPS: Combined positive score.

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Citation: Zheng YH, Wang YY, Wang SC, Wang CJ, Shen YY, Cui JZ, Liu SM, Zhang YH, Zeng XQ, Zhao EH. Clinicopathological, immunohistochemical, and overall-survival associations of poorly cohesive gastric carcinoma stratified by signet ring cell percentage. World J Clin Oncol 2026; 17(10): 125097
URL: https://www.wjgnet.com/2218-4333/full/v17/i10/125097.htm
DOI: https://dx.doi.org/10.5306/wjco.125097

Zheng YH, Wang YY, Wang SC, Wang CJ, Shen YY, Cui JZ, Liu SM, Zhang YH, Zeng XQ, Zhao EH. Clinicopathological, immunohistochemical, and overall-survival associations of poorly cohesive gastric carcinoma stratified by signet ring cell percentage. World J Clin Oncol 2026; 17(10): 125097 [DOI: 10.5306/wjco.125097]

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