Clinicopathological, immunohistochemical, and overall-survival associations of poorly cohesive gastric carcinoma stratified by signet ring cell percentage

doi:10.5306/wjco.125097

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World Journal of Clinical Oncology

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2218-4333

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Retrospective Cohort Study

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World J Clin Oncol. Oct 24, 2026; 17(10): 125097
Published online Oct 24, 2026. doi: 10.5306/wjco.125097

Table 2 Clinicopathological features of defined subtypes within poorly cohesive carcinoma, n (%)

		SRC	SRC/PCC-NOS	PCC-NOS	P value
n		70	171	133
Age, mean (SD)		60.39 (11.09)	58.30 (12.76)	61.62 (10.75)	0.048
Sex	Female	37 (52.9)	95 (55.6)	44 (33.1)	< 0.001
Sex	Male	33 (47.1)	76 (44.4)	89 (66.9)
Site	Upper	6 (8.8)	12 (7.2)	25 (19.1)	0.024
	Middle	30 (44.1)	79 (47.6)	49 (37.4)
	Lower	32 (47.1)	75 (45.2)	57 (43.5)
Stage	I	35 (51.5)	44 (26.3)	25 (19.4)	< 0.001
	II	12 (17.6)	24 (14.4)	18 (14.0)
	III	19 (27.9)	86 (51.5)	82 (63.6)
	IV	2 (2.9)	13 (7.8)	4 (3.1)
T	T1	28 (41.2)	28 (16.8)	12 (9.3)	< 0.001
	T2	9 (13.2)	27 (16.2)	21 (16.3)
	T3	2 (2.9)	8 (4.8)	5 (3.9)
	T4	29 (42.6)	104 (62.3)	91 (70.5)
N	N0	45 (64.3)	54 (31.8)	41 (30.8)	< 0.001
	N1	6 (8.6)	22 (12.9)	16 (12.0)
	N2	7 (10.0)	25 (14.7)	27 (20.3)
	N3	12 (17.1)	69 (40.6)	49 (36.8)
M	M0	67 (97.1)	155 (92.3)	123 (96.9)	0.135
M	M1	2 (2.9)	13 (7.7)	4 (3.1)

Missing data: Age, 0; sex, 0; stage, 10 (2.7%). Percentages are based on the total cohort (n = 374). SRC: Signet ring carcinoma; PCC-NOS: Poorly cohesive carcinoma-not otherwise specified.

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Citation: Zheng YH, Wang YY, Wang SC, Wang CJ, Shen YY, Cui JZ, Liu SM, Zhang YH, Zeng XQ, Zhao EH. Clinicopathological, immunohistochemical, and overall-survival associations of poorly cohesive gastric carcinoma stratified by signet ring cell percentage. World J Clin Oncol 2026; 17(10): 125097
URL: https://www.wjgnet.com/2218-4333/full/v17/i10/125097.htm
DOI: https://dx.doi.org/10.5306/wjco.125097

Zheng YH, Wang YY, Wang SC, Wang CJ, Shen YY, Cui JZ, Liu SM, Zhang YH, Zeng XQ, Zhao EH. Clinicopathological, immunohistochemical, and overall-survival associations of poorly cohesive gastric carcinoma stratified by signet ring cell percentage. World J Clin Oncol 2026; 17(10): 125097 [DOI: 10.5306/wjco.125097]

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