Clinical efficacy of integrated Chinese-Western medicine therapy for metastatic colorectal cancer

doi:10.5306/wjco.124301

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World Journal of Clinical Oncology

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2218-4333

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Oct 24, 2026; 17(10): 124301
Published online Oct 24, 2026. doi: 10.5306/wjco.124301

Table 3 Multivariable Cox proportional hazards regression model

Covariate	β (coefficient)	HR	E-value	95%CI	P value
Treatment (control)	2.705	14.954	29.40	9.054-24.701	< 0.001^a
Sex (male)	0.354	1.424	2.20	1.119-1.813	0.004^a
Age (≥ 60 years)	-0.026	0.974	-	0.781-1.215	0.816
Tumor site (right colon)	0.149	1.161	1.59	0.905-1.491	0.241
Histology (non-adenocarcinoma)	0.455	1.576	2.53	1.058-2.347	0.025^a
Gene type (mutant)	0.533	1.704	2.80	1.354-2.145	< 0.001^a
Prior treatment (first- or second-line vs treatment-naive)	-0.314	0.731	-	0.559-0.955	0.023^a
Prior treatment (third-line or later vs treatment-naive)	0.550	1.734	2.86	1.256-2.393	< 0.001^a
Palliative surgery	-0.132	0.876	-	0.689-1.115	0.283
Prior targeted therapy	-0.069	0.933	-	0.720-1.210	0.603
Comorbidities	0.176	1.192	1.67	0.950-1.495	0.129
TCM deficiency - spleen-kidney	0.175	1.192	1.67	0.874-1.624	0.267
TCM deficiency - liver-kidney	0.452	1.572	2.52	0.959-2.576	0.073
TCM deficiency - liver qi stagnation with spleen deficiency	0.946	2.573	4.58	1.644-4.028	< 0.001^a
TCM deficiency - lung-kidney	-0.038	0.963	-	0.724-1.281	0.795
TCM deficiency - lung-spleen	-0.274	0.760	-	0.477-1.210	0.247
TCM excess - phlegm-stasis obstruction	-0.167	0.846	-	0.632-1.316	0.260
TCM excess - stasis-toxin obstruction	-0.383	0.682	-	0.469-0.992	0.045^a
TCM excess - phlegm-damp retention	-0.121	0.886	-	0.675-1.164	0.386
TCM excess - internal retention of dampness	0.341	1.406	2.16	0.890-2.222	0.144
KPS ≥ 80	-1.315	0.269	-	0.101-0.711	0.008^a
BMI ≥ 24	-0.009	0.991	-	0.967-1.017	0.504
Liver metastasis	0.037	1.037	-	0.818-1.315	0.762
Lung metastasis	-0.102	0.903	-	0.719-1.134	0.380
Brain metastasis	0.641	1.898	3.20	1.024-3.518	0.042^a
Peritoneal metastasis	0.222	1.248	1.80	0.801-1.946	0.327

^aP < 0.05.

HR: Hazard ratio; CI: Confidence interval; TCM: Traditional Chinese medicine; KPS: Karnofsky performance status; BMI: Body mass index.

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Citation: Li R, Xu YY, Wu BB, Wang MM, Guan L, Li BR, Wang YW, Yang YF, Pang B. Clinical efficacy of integrated Chinese-Western medicine therapy for metastatic colorectal cancer. World J Clin Oncol 2026; 17(10): 124301
URL: https://www.wjgnet.com/2218-4333/full/v17/i10/124301.htm
DOI: https://dx.doi.org/10.5306/wjco.124301

Li R, Xu YY, Wu BB, Wang MM, Guan L, Li BR, Wang YW, Yang YF, Pang B. Clinical efficacy of integrated Chinese-Western medicine therapy for metastatic colorectal cancer. World J Clin Oncol 2026; 17(10): 124301 [DOI: 10.5306/wjco.124301]

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