Impact of different surgical approaches on prognosis in patients with pancreatic neck cancer: A retrospective cohort study

doi:10.5306/wjco.124078

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Oct 24, 2026; 17(10): 124078
Published online Oct 24, 2026. doi: 10.5306/wjco.124078

Table 1 Comparison of clinicopathological characteristics among different surgical procedure groups in patients with pancreatic neck cancer, n (%)/mean ± SD/median (interquartile range)

Variable	Type of surgery			P value
Variable	DP (n = 107)	PD (n = 41)	TP (n = 26)	P value
Gender				0.101
Male	45 (42.1)	20 (48.8)	17 (65.4)
Female	62 (57.9)	21 (51.2)	9 (34.6)
Age (years)	65 (59-70)	64 (59-69)	65 (57-67)	0.472
BMI (kg/m²)	22.93 ± 2.69	23.50 ± 3.14	22.75 ± 2.36	0.445
CA19-9 (U/mL)				0.889
< 37	30 (28.0)	13 (31.7)	8 (30.8)
≥ 37	77 (72.0)	28 (68.3)	18 (69.2)
Tumor size (cm)	2.6 (2-3.2)	2.5 (2-3)	4 (3.225-4.5)	< 0.001
Pathological type				0.875
PDAC	97 (90.7)	39 (95.1)	24 (92.3)
IPMN	7 (6.5)	2 (4.9)	1 (3.8)
Others	3 (2.8)	0 (0)	1 (3.8)
T stage				< 0.001
T1-T2	72 (67.3)	32 (78)	9 (34.6)
T3-T4	35 (32.7)	9 (22)	17 (65.4)
N stage				0.860
N0	62 (57.9)	25 (61.0)	14 (53.8)
N1-N2	45 (42.1)	16 (39.0)	12 (46.2)
Grade				0.436
Poorly differentiated	39 (36.4)	13 (31.7)	12 (46.2)
Moderately differentiated	58 (54.2)	27 (65.9)	13 (50.0)
Well differentiated	10 (9.3)	1 (2.4)	1 (3.8)
Intravascular cancer thrombus	36 (33.6)	14 (34.1)	9 (34.6)	1.000
Nerve invasion	83 (77.6)	35 (85.4)	23 (88.5)	0.382
AJCC stage				0.002
I	47 (43.9)	20 (48.8)	3 (11.5)
IIA	4 (3.7)	0 (0)	1 (3.8)
IIB	28 (26.2)	12 (29.3)	5 (19.2)
III	28 (26.2)	9 (22)	17 (65.4)
Number of dissected lymph nodes	16 (12-23)	16 (11-22)	22 (12.5-34.25)	0.160
Number of metastatic lymph nodes	0 (0-1)	0 (0-1)	0 (0-2)	0.745
Lymph node ratio	0 (0-8.33)	0(0-7.69)	0 (0-8.99)	0.910
Surgical margin				0.852
R0	94 (87.9)	35 (85.4)	22 (84.6)
R1	13 (12.1)	6 (14.6)	4 (15.4)
Operative time (minute)	217.92 ± 68.75	296.37 ± 68.46	359.12 ± 74.79	< 0.001
Intraoperative blood loss (mL)	200 (200-400)	300 (200-500)	650 (375-1725)	< 0.001
Postoperative stay (days)	12 (10-14)	13 (11-14)	14 (12-17)	0.005
Neoadjuvant therapy	25 (23.4)	11 (26.8)	11 (42.3)	0.157
Adjuvant therapy	90 (84.1)	35 (85.4)	15 (57.7)	0.007

DP: Distal pancreatectomy; PD: Pancreaticoduodenectomy; TP: Total pancreatectomy; BMI: Body mass index; CA19-9: Carbohydrate antigen 19-9; PDAC: Pancreatic ductal adenocarcinoma; IPMN: Intraductal papillary mucinous neoplasm; AJCC: American Joint Committee on Cancer; R0: Microscopically margin-negative resection; R1: Microscopically margin-positive resection.

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Citation: Ma MJ, Cheng H, Chen YS, Yu XJ, Liu C. Impact of different surgical approaches on prognosis in patients with pancreatic neck cancer: A retrospective cohort study. World J Clin Oncol 2026; 17(10): 124078
URL: https://www.wjgnet.com/2218-4333/full/v17/i10/124078.htm
DOI: https://dx.doi.org/10.5306/wjco.124078

Ma MJ, Cheng H, Chen YS, Yu XJ, Liu C. Impact of different surgical approaches on prognosis in patients with pancreatic neck cancer: A retrospective cohort study. World J Clin Oncol 2026; 17(10): 124078 [DOI: 10.5306/wjco.124078]

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