Ferritin as a novel predictive index for nasopharyngeal carcinoma survival and therapeutic efficacy of different chemotherapy regimens

Table 4 Association between Ferritin index related indicators and 5-year mortality (Cox regression)

Variable	Model 1		Model 2		Model 3
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Continuous Ferritin value	0.99 (0.99-0.99)	< 0.001a	0.99 (0.99-0.99)	< 0.001a	1.03 (1.01-1.05)	0.046a
Ferritin quartile
1	1.00 (reference)		1.00 (reference)		1.00 (reference)
2	0.27 (0.18-0.40)	< 0.001a	0.18 (0.10-0.31)	< 0.001a	0.01 (0.00-0.02)	< 0.001a
3	0.36 (0.24-0.52)	< 0.001a	0.32 (0.19-0.54)	< 0.001a	0.02 (0.01-0.05)	< 0.001a
4	0.21 (0.13-0.34)	< 0.001a	0.16 (0.08-0.30)	< 0.001a	19.19 (6.15-59.88)	< 0.001a

^aP < 0.05.

Model 1: Crude. Model 2: Adjusted for age and sex. Model 3: Adjusted for age, sex, tumor stage, tumor associated material, tumor supplied group of factors, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, gamma-glutamyl transferase, glycyl-proline-dipeptidyl aminopeptidase, and neuron-specific enolase levels. HR: Hazard ratio.