Ferritin as a novel predictive index for nasopharyngeal carcinoma survival and therapeutic efficacy of different chemotherapy regimens

Table 3 Weighted baseline characteristics by quartiles of the Ferritin index

Ferritin index	Quartile 1 (1.89-83.13)	Quartile 2 (83.18-129.21)	Quartile 3 (130.65-175.25)	Quartile 4 (175.68-378.29)	Statistic	P value
Age	44.31 ± 10.51	45.90 ± 11.01	46.95 ± 9.46	47.66 ± 8.70	F = 1.94	0.122
TAM	92.71 ± 11.71	96.23 ± 14.10	90.62 ± 11.22	91.41 ± 14.77	F = 0.56	0.645
TSGF	52.11 ± 15.94	52.25 ± 18.33	51.70 ± 17.98	54.60 ± 18.68	F = 0.42	0.736
AST	22.16 ± 7.34	23.52 ± 26.25	23.61 ± 9.15	23.78 ± 14.54	F = 0.19	0.902
ALT	22.07 ± 13.33	29.38 ± 55.16	27.47 ± 18.35	27.73 ± 23.93	F = 0.88	0.453
ALP	75.24 ± 35.52	75.57 ± 23.04	74.70 ± 17.44	83.76 ± 42.89	F = 1.47	0.222
LDH	175.75 ± 46.90	167.67 ± 45.76	173.61 ± 40.56	179.49 ± 51.28	F = 0.93	0.428
GGT	27.34 ± 25.41	36.67 ± 50.42	37.54 ± 39.92	54.94 ± 146.71	F = 1.63	0.182
5-NT	5.66 ± 4.42	6.24 ± 5.18	6.39 ± 4.82	6.94 ± 7.87	F = 0.67	0.571
GPDA	70.79 ± 20.37	65.42 ± 25.22	72.53 ± 23.03	74.70 ± 28.84	F = 2.11	0.099
ADA	13.85 ± 7.51	15.42 ± 14.51	16.90 ± 18.88	13.91 ± 9.46	F = 0.93	0.426
MAO	4.71 ± 2.50	4.78 ± 2.00	5.30 ± 2.58	5.12 ± 2.72	F = 1.02	0.385
NSE	2.07 ± 1.30	2.64 ± 1.61	2.88 ± 2.08	2.88 ± 2.51	F = 3.55	0.015a
CEA	1.13 ± 0.79	1.57 ± 2.22	1.36 ± 1.07	1.58 ± 1.43	F = 1.91	0.127
AFP	1.28 ± 1.13	1.94 ± 2.91	2.01 ± 2.12	1.71 ± 1.76	F = 2.29	0.078
Tumor stage (%)					-	0.838
I	0	0	0	0
II	5.06	6.10	4.94	5.13
III	54.43	54.88	54.32	42.31
IVa	36.71	34.15	35.80	43.59
IVb	3.80	4.88	4.94	8.97
Gender (%)					χ² = 44.94	< 0.001a
Male	41.76	76.92	82.42	76.92
Female	58.24	23.08	17.58	23.08
3-year survivors (%)					χ² = 34.13	< 0.001a
Death	3.30	29.67	31.87	38.46
Survival	96.70	70.33	68.13	61.54
5-year survivors (%)					χ² = 97.78	< 0.001a
Death	8.79	62.64	57.14	78.02
Survival	91.21	37.36	42.86	21.98

^aP < 0.05.

F: ANOVA. -: Fisher’s exact test. TAM: Tumor-associated material; TSGF: Tumor-supplied group of factors; NSE: Neuron-specific enolase; CEA: Carcinoembryonic antigen; AFP: Alpha-fetoprotein; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; LDH: Lactate dehydrogenase; GGT: Gamma-glutamyl transferase; 5-NT: 5'-Nucleotidase; GPDA: Glycyl-proline-dipeptidyl aminopeptidase; ADA: Adenosine deaminase; MAO: Monoamine oxidase.