Ferritin as a novel predictive index for nasopharyngeal carcinoma survival and therapeutic efficacy of different chemotherapy regimens

Table 1 Baseline characteristics between survivors and non-survivors, n (%)

Variable	Total (n = 1142)	Survivors (n = 615)	Non-survivors (n = 527)	Statistic	P value
Gender
Male	783 (68.56)	407 (66.18)	376 (71.35)
Female	359 (31.44)	208 (33.82)	151 (28.65)
Age (years)
≤ 29	47 (4.12)	36 (76.60)	11 (23.40)
30-39	202 (17.69)	132 (65.35)	70 (34.65)
40-49	522 (45.70)	268 (51.34)	254 (48.66)
50-59	279 (24.43)	138 (49.46)	141 (50.54)
60-69	88 (7.71)	41 (46.59)	47 (53.41)
≥ 70	4 (0.35)	0 (0)	4 (100)
Tumor stage (%)				χ² = 6.08	0.193
I	0.47	0.73	0.23
II	5.44	7.07	3.90
III	54.61	56.65	52.44
IVa	35.46	34.86	36.10
IVb	4.02	3.66	4.36
TAM (U/mL)	89.27 ± 12.43	87.73 ± 11.09	90.89 ± 13.60	t = 1.42	0.159
TSGF (U/mL)	54.40 ± 17.22	54.37 ± 17.19	54.43 ± 17.28	t = 0.05	0.959
NSE (ng/mL)	2.61 ± 1.95	2.55 ± 2.11	2.68 ± 1.79	t = 0.61	0.539
CEA (mg/L)	1.41 ± 1.48	1.22 ± 0.95	1.58 ± 1.83	t = 2.36	0.019
Feritin (ng/mL)	133.42 ± 76.11	97.32 ± 68.38	167.22 ± 67.04	t = 9.84	< 0.001
AFP (ng/mL)	1.73 ± 2.09	1.65 ± 2.12	1.82 ± 2.05	t = 0.77	0.444
AST (U/L)	23.45 ± 16.30	23.58 ± 17.14	23.30 ± 15.35	t = -0.26	0.798
ALT (U/L)	26.83 ± 29.59	27.39 ± 29.30	26.22 ± 29.93	t = -0.60	0.547
ALP (U/L)	75.67 ± 27.43	75.33 ± 28.26	76.04 ± 26.52	t = 0.38	0.706
LDH (U/L)	172.59 ± 42.86	169.30 ± 42.23	176.27 ± 43.32	t = 2.36	0.018
GGT (U/L)	33.87 ± 53.87	31.13 ± 27.63	36.90 ± 72.44	t = 1.55	0.122
5-NT (U/L)	6.07 ± 5.51	5.91 ± 5.14	6.25 ± 5.89	t = 0.89	0.371
GPDA (U/L)	67.91 ± 21.38	68.18 ± 20.06	67.61 ± 22.76	t = -0.38	0.704
ADA (U/L)	15.18 ± 23.80	14.58 ± 17.97	15.83 ± 28.91	t = 0.75	0.450
MAO (U/L)	4.77 ± 2.37	4.75 ± 2.33	4.80 ± 2.41	t = 0.26	0.794

TAM: Tumor-associated material; TSGF: Tumor-supplied group of factors; NSE: Neuron-specific enolase; CEA: Carcinoembryonic antigen; AFP: Alpha-fetoprotein; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; LDH: Lactate dehydrogenase; GGT: Gamma-glutamyl transferase; 5-NT: 5'-Nucleotidase; GPDA: Glycyl-proline-dipeptidyl aminopeptidase; ADA: Adenosine deaminase; MAO: Monoamine oxidase.