Kita-Kyushu lung cancer antigen-1 expression in initial gastric tumors predicts multiple cancer development: A pilot study

Table 4 Correlation between Kita-Kyushu lung cancer antigen-1 expression and clinical pathological factors in initial gastric cancer in the middle and lower region, n (%)/median (interquartile range)

	KK-LC-1 expression
	Positive	Negative	P value
Sex			0.322
Male	39 (66.1)	20 (33.9)
Female	21 (77.8)	6 (22.2)
Age	77.0 (70.0-81.0)	71.5 (58.3-77.8)	0.020
Depth of invasion			0.192
T1	46 (74.2)	16 (25.8)
T2-T4	14 (58.3)	10 (41.7)
Histological type			0.022
Differentiated	46 (80.0)	13(22.0)
Undifferentiated	14 (51.9)	13 (48.1)
Tumor diameter			0.816
≤ 20 mm	30 (68.2)	14 (31.8)
> 20 mm	30 (71.4)	12 (28.6)
Lymph node metastasis			0.158
Positive	10 (55.6)	8 (44.4)
Negative	50 (73.5)	18 (26.5)
Lymphatic invasion			0.614
Positive	17 (65.4)	9 (34.6)
Negative	43 (71.7)	17 (28.3)
Venous invasion			0.453
Positive	16 (64.0)	9 (36.0)
Negative	44 (72.1)	17 (27.9)
Pathological stage			0.417
I	47 (72.3)	18 (27.7)
II, III, IV	13 (61.9)	8 (38.1)
Treatment			0.097
Endoscopic	38 (77.6)	11 (22.4)
Surgery	22 (59.5)	15 (40.5)
Atrophic gastritis (n = 84)			0.579
Yes	57 (71.3)	23 (28.8)
No	2 (50.0)	2 (50.0)
Anti-H. pylori antibody titer (n = 79)			0.214
Positive	20 (60.6)	13 (39.4)
Negative	35 (76.1)	11 (23.9)
H. pylori eradication (n = 78)			0.142
Yes	26 (78.8)	7 (21.2)
No	28 (62.2)	17 (37.8)
Multiple cancers			0.002
Multiple	16 (100)	0 (0)
Single	44 (62.9)	26 (37.1)

H. pylori: Helicobacter pylori; KK-LC-1: Kita-Kyushu lung cancer antigen-1.