Kita-Kyushu lung cancer antigen-1 expression in initial gastric tumors predicts multiple cancer development: A pilot study

Table 3 Correlation of Kita-Kyushu lung cancer antigen-1 expression and clinicopathological factors in initial gastric cancer, n (%)/median (interquartile range)

	KK-LC-1 expression
	Positive	Negative	P value
Sex			0.341
Male	54 (67.5)	26 (43.3)
Female	23 (79.3)	6 (20.7)
Age	77 (70.0-81.0)	74 (59.8-79.5)	0.078
Depth of invasion			0.110
T1	61 (74.4)	21 (25.6)
T2-T4	16 (59.3)	11 (40.7)
Histological type			0.035
Differentiated	60 (76.9)	18 (23.1)
Undifferentiated	17 (54.8)	14 (45.2)
Tumor diameter			1
≤ 20 mm	38 (70.4)	16 (29.6)
> 20 mm	39 (70.9)	16 (29.1)
Lymph node metastasis			0.073
Positive	12 (54.5)	10 (45.5)
Negative	65 (74.7)	22 (25.3)
Lymphatic invasion			0.371
Positive	23 (63.9)	13 (36.1)
Negative	54 (74.0)	19 (26.0)
Venous invasion			0.254
Positive	20 (62.5)	12 (37.5)
Negative	57 (74.0)	20 (26.0)
Pathological stage			0.150
I	61 (74.4)	21 (25.6)
II, III, IV	16 (59.3)	11 (40.7)
Treatment			0.091
Endoscopic	46 (78.0)	13 (22.0)
Surgery	31 (62.0)	19 (38.0)
Atrophic gastritis (n = 106)			0.355
Yes	72 (72.0)	28 (28.0)
No	3 (50.0)	3 (50.0)
Anti-H. pylori antibody titer (n = 101)			0.279
Positive	27 (64.3)	15 (35.7)
Negative	44 (74.6)	15 (25.4)
H. pylori eradication (n = 99)			0.027
Yes (n = 40)	33 (82.5)	7 (17.5)
No (n = 59)	36 (61.0)	23 (39.0)
Multiple cancers			0.016
Multiple	24 (88.9)	3 (11.1)
Single	53 (64.6)	29 (35.4)
Location			0.800
Upper	17 (73.9)	6 (26.1)
Middle and lower	60 (69.8)	26 (30.2)

H. pylori: Helicobacter pylori; KK-LC-1: Kita-Kyushu lung cancer antigen-1.