Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms

doi:10.5306/wjco.v17.i1.112801

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Jan 24, 2026; 17(1): 112801
Published online Jan 24, 2026. doi: 10.5306/wjco.v17.i1.112801

Table 9 Kaplan-Meier survival curve for overall survival with different parameters (n = 90), mean ± SD

Parameter	Group (n)	Mean OS (months)	Survival at endpoint (%)	Log-rank χ²	P value	Hazard ratio (95%CI)
SII	Low (45)	25.211 ± 2.50	70.0	0.021	0.884	1.10 (0.80-1.50)
SII	High (45)	25.104 ± 2.45	50.0	0.021	0.884	1.10 (0.80-1.50)
SIRI	Low (45)	29.167 ± 1.20	85.0	8.026	0.005^b	1.80 (1.20-2.70)
SIRI	High (45)	23.452 ± 2.30	40.0	8.026	0.005^b	1.80 (1.20-2.70)
PD-L1/CXCR3	Low (45)	29.367 ± 1.10	80.0	6.999	0.008^b	1.90 (1.25-2.90)
PD-L1/CXCR3	High (45)	23.575 ± 2.40	40.0	6.999	0.008^b	1.90 (1.25-2.90)
PD-1/CXCR3	Low (45)	24.067 ± 1.50	80.0	6.381	0.012^a	1.70 (1.15-2.50)
PD-1/CXCR3	High (45)	23.630 ± 2.50	40.0	6.381	0.012^a	1.70 (1.15-2.50)
CXCR3/T lymphocytes (%)	Low (45)	29.167 ± 1.20	80.0	7.239	0.007^b	1.85 (1.20-2.80)
CXCR3/T lymphocytes (%)	High (45)	23.534 ± 2.30	40.0	7.239	0.007^b	1.85 (1.20-2.80)
CXCR3/classical monocytes (%)	Low (45)	24.026 ± 1.80	50.0	4.925	0.026^a	1.50 (1.00-2.25)
CXCR3/classical monocytes (%)	High (45)	27.804 ± 1.50	75.0	4.925	0.026^a	1.50 (1.00-2.25)
CXCR3/intermediate monocytes (%)	Low (45)	23.782 ± 2.00	40.0	7.281	0.007^b	1.60 (1.05-2.40)
CXCR3/intermediate monocytes (%)	High (45)	28.133 ± 1.40	50.0	7.281	0.007^b	1.60 (1.05-2.40)
CXCR3/non-classical monocytes (%)	Low (45)	24.174 ± 1.90	50.0	3.490	0.062	1.30 (0.85-2.00)
CXCR3/non-classical monocytes (%)	High (45)	26.980 ± 1.60	50.0	3.490	0.062	1.30 (0.85-2.00)

^aP < 0.05.

^bP < 0.01.

SII: Systemic immune-inflammation index; SIRI: Systemic inflammation response index; PD-L1: Programmed death-ligand 1; CXCR3: C-X-C motif chemokine receptor 3; PD-1: Programmed cell death protein 1; OS: Overall survival; CI: Confidence interval.

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Citation: Sherief DE, Nosair N, Abdelhameed AM, Sadaka E, Othman AAA, Elgamal R. Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms. World J Clin Oncol 2026; 17(1): 112801
URL: https://www.wjgnet.com/2218-4333/full/v17/i1/112801.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i1.112801

Sherief DE, Nosair N, Abdelhameed AM, Sadaka E, Othman AAA, Elgamal R. Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms. World J Clin Oncol 2026; 17(1): 112801 [PMID: 41608342 DOI: 10.5306/wjco.v17.i1.112801]

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