Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms

doi:10.5306/wjco.v17.i1.112801

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Jan 24, 2026; 17(1): 112801
Published online Jan 24, 2026. doi: 10.5306/wjco.v17.i1.112801

Table 6 Biomarker levels across lymphoma subtypes (n = 90), mean ± SD

Parameter	CLL (n = 40)	DLBCL (n = 30)	Follicular (n = 14)	Mantle cell (n = 6)	P value
SII	19654.6 ± 9090.0	40893.3 ± 10472.1	38427.1 ± 11682.8	39416.7 ± 14621.4	< 0.001^a
SIRI	447.3 ± 130.5	87.09 ± 41.71	105.2 ± 56.61	96.77 ± 65.02	< 0.001^a
PD-L1/CXCR3 (%)	50.71 ± 17.77	51.51 ± 15.98	49.87 ± 17.47	54.50 ± 15.86	0.745
PD-1/CXCR3 (%)	12.14 ± 1.60	12.48 ± 1.29	12.10 ± 1.43	12.67 ± 1.51	0.638
CXCR3/T lymphocytes (%)	52.65 ± 9.76	48.37 ± 8.84	54.69 ± 8.60	60.0 ± 1.79	0.383
CXCR3/classical monocytes (%)	19.95 ± 2.94	11.0 ± 2.86	9.14 ± 3.57	9.17 ± 4.49	< 0.001^a
CXCR3/intermediate monocytes (%)	26.58 ± 4.93	17.60 ± 4.81	12.86 ± 3.82	13.17 ± 4.07	< 0.001^a
CXCR3/non-classical monocytes (%)	20.80 ± 4.43	13.23 ± 5.16	5.71 ± 1.27	6.83 ± 1.17	< 0.001^a

^aP < 0.001.

SII: Systemic immune-inflammation index; SIRI: Systemic inflammation response index; PD-L1: Programmed death-ligand 1; CXCR3: C-X-C motif chemokine receptor 3; PD-1: Programmed cell death protein 1; CLL: Chronic lymphocytic leukemia; DLBCL: Diffuse large B-cell lymphoma.

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Citation: Sherief DE, Nosair N, Abdelhameed AM, Sadaka E, Othman AAA, Elgamal R. Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms. World J Clin Oncol 2026; 17(1): 112801
URL: https://www.wjgnet.com/2218-4333/full/v17/i1/112801.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i1.112801

Sherief DE, Nosair N, Abdelhameed AM, Sadaka E, Othman AAA, Elgamal R. Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms. World J Clin Oncol 2026; 17(1): 112801 [PMID: 41608342 DOI: 10.5306/wjco.v17.i1.112801]

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